Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
GC-MS Chemical Profiling, Biological Investigation of Three Salvia Species Growing in Uzbekistan
Molecules · Eylül 2022
YÖKSİS Kayıtları
GC-MS Chemical Profiling, Biological Investigation of Three Salvia Species Growing in Uzbekistan
Molecules · 2022 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiMolecules
Yayın TarihiEylül 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85137579166
Erişim🔓 Açık Erişim
Özet
Salvia is a potentially valuable aromatic herb that has been used since ancient times. The present work studied the chemical profile of three Salvia species essential oils (EO): S. officinalis, S. virgata and S. sclarea, as well as assessing their antioxidant and enzyme inhibitory activities. A total of 144 compounds were detected by GC-MS analysis, representing 91.1, 84.7 and 78.1% in S. officinalis, S. virgata and S. sclarea EOs, respectively. The major constituents were cis-thujone, 2,4-hexadienal and 9-octadecenoic acid, respectively. The principal component analysis (PCA) score plot revealed significant discrimination between the three species. The antioxidant activity of the EOs was evaluated using in vitro assays. Only S. virgata EO showed antioxidant activity in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay (26.6 ± 1.60 mg Trolox equivalent (TE)/g oil). Moreover, this oil exhibited the highest antioxidant activity in 2,2-azino bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cupric-reducing antioxidant capacity (CUPRAC) and ferric-reducing power (FRAP) assays in comparison with the other two EOs (190.1 ± 2.04 vs. 275.2 ± 8.50 and 155.9 ± 1.33 mg TE/g oil, respectively). However, S. virgata oil did not show any effect in the chelating ability assay, while in the PBD assay, S. officinalis had the best antioxidant activity (26.4 ± 0.16 mmol TE/g oil). Enzyme inhibitory effect of the EOs was assessed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), tyrosinase, α-glucosidase and α-amylase. AChE enzyme was more sensitive to S. officinalis EO (4.2 ± 0.01 mg galantamine equivalent (GALAE)/g oil), rather than S. virgata EO, which was ineffective. However, S. virgata had the highest BChE effect (12.1 ± 0.16 mg GALAE/g oil). All studied oils showed good tyrosinase inhibitory activity, ranging between 66.1 ± 0.61 and 128.4 ± 4.35 mg kojic acid equivalent (KAE)/g oil). Moreover, the EOs did not exhibit any glucosidase inhibition and were weak or inefficient on amylase enzyme. Partial least squares regression (PLS-R) models showed that there is an excellent correlation between the antioxidant activity and the volatile profile when being compared to that of enzyme inhibitory activity. Thus, the studied Salvia essential oils are interesting candidates that could be used in drug discovery for the management of Alzheimer’s and hyperpigmentation conditions.
Yazarlar (9)
1
Haidy A. Gad
ORCID: 0000-0002-2951-983X
2
Rano Mamadalieva
3
Noha Khalil
ORCID: 0000-0002-1957-2127
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Basma Najar
6
Olim K. Khojimatov
ORCID: 0000-0003-1631-8841
7
Nawal M. Al Musayeib
8
Mohamed L. Ashour
ORCID: 0000-0002-9270-6267
9
Nilufar Z. Mamadalieva
ORCID: 0000-0003-1756-3638
Anahtar Kelimeler
antioxidants
chemical profile
chemometric analysis
enzyme inhibition
GC-MS
Salvia
Kurumlar
Academy of Sciences of the Republic of Uzbekistan
Tashkent Uzbekistan
College of Pharmacy
Riyadh Saudi Arabia
Faculty of Pharmacy
New Cairo Egypt
Faculty of Pharmacy - Ain Shams University
Cairo Egypt
Institute of Botany, Uzbekistan
Tashkent Uzbekistan
Kokand State Pedagogical Institute
Kokand Uzbekistan
Selçuk Üniversitesi
Selçuklu Turkey
Università di Pisa
Pisa Italy
Metrikler
9
Atıf
9
Yazar
6
Anahtar Kelime