Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species
Molecules · Eylül 2022
YÖKSİS Kayıtları
Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species
Molecules · 2022 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiMolecules
Yayın TarihiEylül 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85137608089
Erişim🔓 Açık Erişim
Özet
Several species within the genera Cassia or Senna have a treasure of traditional medicines worldwide and can be a promising source of bioactive molecules. The objective of the present study was to evaluate the phenolic content and antioxidant and enzyme inhibition activities of leaf methanolic extracts of C. fistula L., C. grandis L., S. alexandrina Mill., and S. italica Mill. The two Cassia spp. contained higher total polyphenolic content (42.23–49.75 mg GAE/g) than the two Senna spp., and C. fistula had significantly (p ˂ 0.05) the highest concentration. On the other hand, the Senna spp. showed higher total flavonoid content (41.47–59.24 mg rutin equivalent per g of extract) than that found in the two Cassia spp., and S. alexandrina significantly (p ˂ 0.05) accumulated the highest amount. HPLC–MS/MS analysis of 38 selected bioactive compounds showed that the majority of compounds were identified in the four species, but with sharp variations in their concentrations. C. fistula was dominated by epicatechin (8928.75 µg/g), C. grandis by kaempferol-3-glucoside (47,360.04 µg/g), while rutin was the major compound in S. italica (17,285.02 µg/g) and S. alexandrina (6381.85). The methanolic extracts of the two Cassia species exerted significantly (p ˂ 0.05) higher antiradical activity, metal reducing capacity, and total antioxidant activity than that recorded from the two Senna species’ methanolic extracts, and C. fistula displayed significantly (p ˂ 0.05) the highest values. C. grandis significantly (p ˂ 0.05) exhibited the highest metal chelating power. The results of the enzyme inhibition activity showed that the four species possessed anti-AChE activity, and the highest value, but not significantly (p ≥ 0.05) different from those obtained by the two Cassia spp., was exerted by S. alexandrina. The Cassia spp. exhibited significantly (p ˂ 0.05) higher anti-BChE and anti-Tyr properties than the Senna spp., and C. grandise revealed significantly (p ˂ 0.05) the highest values. C. grandise revealed significantly (p ˂ 0.05) the highest α- amylase inhibition, while the four species had more or less the same effect against the α-glucosidase enzyme. Multivariate analysis and in silico studies showed that many of the identified phenols may play key roles as antioxidant and enzyme inhibitory properties. Thus, these Cassia and Senna species could be a promising source of natural bioactive agents with beneficial effects for human health.
Yazarlar (9)
1
Haifa A.A. Omer
2
Giovanni Caprioli
ORCID: 0000-0002-5530-877X
3
Doaa Abouelenein
ORCID: 0000-0001-6053-3712
4
Ahmed M. Mustafa
5
Abdullahi Ibrahim Uba
6
Gunes Ak
7
Refiye Beyza Ozturk
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
9
Sakina Yagi
Anahtar Kelimeler
antioxidant
Cassiaspp
enzyme inhibition
phenolic compounds
Sennaspp
Kurumlar
Kadir Has Üniversitesi
Istanbul Turkey
Khartoum University
Khartoum Sudan
Selçuk Üniversitesi
Selçuklu Turkey
Sudan University of Science and Technology
Khartoum Sudan
Università degli Studi di Camerino
Camerino Italy
Metrikler
26
Atıf
9
Yazar
5
Anahtar Kelime