Scopus
🔓 Açık Erişim
Chemical Profiling and Biological Activities of Pelargonium graveolens Essential Oils at Three Different Phenological Stages
Plants · Eylül 2022
Makale Bilgileri
DergiPlants
Yayın TarihiEylül 2022
Cilt / Sayfa11
Scopus ID2-s2.0-85137763970
Erişim🔓 Açık Erişim
Özet
The aim of this work was the determination of Pelargonium graveolens (aerial parts) volatile compounds at three developmental stages and the evaluation of their antioxidant, antidiabetic, dermaprotective, anti-inflammatory, and antibacterial effects. The aerial parts of Pelargonium graveolens were collected at three stages, namely the vegetative, beginning, and full flowering. Pelargonium graveolens essential oils were extracted from the dried materials of these aerial parts by hydrodistillation. The volatiles were analyzed by Gas Chromatography-Mass Spectrometry GC-MS, and the antioxidant activity was assessed by DPPH, ABTS, H2O2, and FRAP assays. The in vitro antidiabetic effect was evaluated by the inhibition of α-amylase, α-glucosidase, and lipase enzymes, while the antibacterial activity was assessed against six bacterial strains using an agar well diffusion assay and a microdilution method. The main constituents were menthol, menthene, eremophilene, isoborneol, isogeraniol, α-pinene, linalyl acetate, and 3-carene, with quantitative differences at the three phenological stages. The essential oil at the full flowering stage showed the best antioxidant activity, with IC50 values of 83.26 ± 0.01, 116.42 ± 0.07, 132.25 ± 0.11, and 48.67 ± 0.04 μg/mL for DPPH, FRAP, ABTS, and H2O2 assays, respectively. This oil also exhibited significant effects against α-amylase (IC50 = 43.33 ± 0.01 μg/mL), α-glucosidase (IC50 = 19.04 ± 0.01 μg/mL), lipase (IC50 = 24.33 ± 0.05 μg/mL), 5-lipoxygenase (IC50 = 39.31 ± 0.01 μg/mL), and tyrosinase (IC50 = 124.49 ± 0.07 μg/mL). The essential oil extracted at the full flowering stage showed the best antibacterial effect against a panel of microorganisms with diameter inhibition zones ranging between 11.00 ± 0.17 mm and 17.30 ± 0.17 mm and MIC values from 0.25% to 2% v/v. Overall, the results presented here suggest that the full flowering stage is the best optimal harvest time of Pelargonium graveolens for food and pharmaceutical applications.
Yazarlar (14)
1
Samiah Hamad Al-Mijalli
2
Hanae Naceiri Mrabti
3
Hamza Assaggaf
ORCID: 0000-0001-5563-9491
4
Ammar A. Attar
5
Munerah Hamed
6
Aicha El Baaboua
7
Nasreddine El Omari
8
Naoual El Menyiy
9
Zakaria Hazzoumi
10
Ryan A. Sheikh
ORCID: 0000-0003-3275-0861
11
Gokhan Zengin
ORCID: 0000-0001-6548-7823
12
Stefania Sut
13
Stefano Dall'Acqua
14
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
Anahtar Kelimeler
antibacterial
antidiabetic
anti-inflammatory
essential oils
Pelargonium graveolens
Kurumlar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
King Abdulaziz University
Jeddah Saudi Arabia
Moroccan Foundation for Advanced Science
Rabat Morocco
National Agency of Medicinal and Aromatic Plants
Taounate Morocco
Princess Nourah Bint Abdulrahman University
Riyadh Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
Umm Al-Qura University
Makkah Saudi Arabia
Università degli Studi di Padova
Padua Italy
Université Abdelmalek Essaadi
Tetouan Morocco
Metrikler
24
Atıf
14
Yazar
5
Anahtar Kelime