Scopus
🔓 Açık Erişim
Determination of Chemical Compounds and Investigation of Biological Properties of Matricaria chamomilla Essential Oils, Honey, and Their Mixture
Molecules · Eylül 2022
Makale Bilgileri
DergiMolecules
Yayın TarihiEylül 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85138358736
Erişim🔓 Açık Erişim
Özet
This exploratory investigation aimed to determine the chemical composition and evaluate some biological properties, such as antioxidant, anti-inflammatory, antidiabetic, and antimicrobial activities, of Matricaria chamomilla L. essential oils (EOs). EOs of M. chamomilla were obtained by hydrodistillation and phytochemical screening was performed by gas chromatography–mass spectrophotometry (GC-MS). The antimicrobial activities were tested against different pathogenic strains of microorganisms by using disc diffusion assay, the minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) methods. The antidiabetic activity was performed in vitro using the enzyme inhibition test. The antioxidant activity of EOs was tested using the free radical scavenging ability (DPPH method), ferrous ion chelating (FIC) ability, and β-carotene bleaching assay. The anti-inflammatory effects were tested in vivo using the carrageenan-induced paw edema method and in vitro using the inhibition of the lipoxygenase test. The analysis of the phytochemical composition by GC-MS revealed that camphor (16.42%) was the major compound of EOs, followed by 3-carene (9.95%), β-myrcene (8.01%), and chamazulene (6.54%). MCEO, honey, and their mixture exhibited antioxidant activity against the DPPH assay (IC50 ranging from 533.89 ± 15.05 µg/mL to 1945.38 ± 12.71 µg/mL). The mixture exhibited the best radical scavenging activity, with an IC50 of 533.89 ± 15.05 µg/mL. As antidiabetic effect, EO presented the best values against α-glucosidase (265.57 ± 0.03 μg/mL) and α-amylase (121.44 ± 0.05 μg/mL). The EOs and honey mixture at a dose of 100 mg/kg exhibited a high anti-inflammatory effect, with 63.75% edema inhibition after 3 h. The impact of EOs on the studied species showed an excellent antimicrobial (Staphylococcus aureus ATCC 29213 (22.97 ± 0.16 mm)), antifungal (Aspergillus niger (18.13 ± 0.18 mm)) and anti-yeast (Candida albicans (21.07 ± 0.24 mm) effect against all the tested strains. The results obtained indicate that the EOs of M. chamomilla could be a potential drug target against diabetes, inflammation and microbial infections; however, further investigations to assess their bioactive molecules individually and in combination are greatly required.
Yazarlar (15)
1
Ahmed Qasem
ORCID: 0000-0002-6681-5363
2
Hamza Assaggaf
ORCID: 0000-0001-5563-9491
3
Domenico Montesano
ORCID: 0000-0002-8857-2091
4
Zineb Khalil
5
Samiah Hamad Al-Mijalli
6
Aicha El Baaboua
7
Nasreddine El Omari
8
Naoual El Menyiy
9
Saad Bakrim
10
Ryan A. Sheikh
ORCID: 0000-0003-3275-0861
11
Mohammed Merae Alshahrani
ORCID: 0000-0002-9387-5492
12
Ahmed Abdullah Al Awadh
ORCID: 0000-0001-5860-530X
13
Gokhan Zengin
ORCID: 0000-0001-6548-7823
14
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
15
Hanae Naceiri Mrabti
Anahtar Kelimeler
antidiabetic activity
anti-inflammatory effect
antimicrobial activity
antioxidant effect
essential oils
Matricaria chamomillaL
Kurumlar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
King Abdulaziz University
Jeddah Saudi Arabia
Najran University
Najran Saudi Arabia
National Agency of Medicinal and Aromatic Plants
Taounate Morocco
Princess Nourah Bint Abdulrahman University
Riyadh Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
Umm Al-Qura University
Makkah Saudi Arabia
Università degli Studi di Napoli Federico II
Naples Italy
Université Abdelmalek Essaadi
Tetouan Morocco
Université Ibn Zohr
Agadir Morocco
Metrikler
11
Atıf
15
Yazar
6
Anahtar Kelime