Scopus
🔓 Açık Erişim
The Current State of Knowledge in Biological Properties of Cirsimaritin
Antioxidants · Eylül 2022
Makale Bilgileri
DergiAntioxidants
Yayın TarihiEylül 2022
Cilt / Sayfa11
Scopus ID2-s2.0-85138578985
Erişim🔓 Açık Erişim
Özet
The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbatus, Microtea debilis, and Ocimum sanctum, has been carried out and verified using different spectral techniques. Biological effect investigations are carried out with a wide variety of experimental models in vitro and in vivo and laboratory techniques. The results of these research works showed the biological properties of cirsimaritin including anticancer, antimicrobial, antidiabetic, antiparasitic, antioxidant, and anti-inflammatory effects. The mechanisms involved in the multiple activities of this molecule are diverse and include sub-cellular, cellular, and molecular levels. Indeed, this bioactive induces anti-inflammatory and antiproliferative effects by inhibiting cell membrane receptors, interference with signaling pathways, and inhibiting transcriptional factors such as Nf-κB involved in cell promotion and proliferation. In the light of these results, cirsimaritin appears as a promising and viable alternative natural bioactive drug to treat many pathological conditions.
Yazarlar (16)
1
Taoufiq Benali
2
Imane Jouadi
ORCID: 0000-0003-0753-1667
3
Rokia Ghchime
4
Nasreddine El Omari
5
Kaoutar Harboul
6
Khalil Hammani
7
Maksim Rebezov
8
Mohammad Ali Shariati
ORCID: 0000-0001-9376-5771
9
Mohammad S. Mubarak
ORCID: 0000-0002-9782-0835
10
Jesus Simal-Gandara
11
Gokhan Zengin
ORCID: 0000-0001-6548-7823
12
Moon Nyeo Park
13
Bonglee Kim
ORCID: 0000-0002-8678-156X
14
Shafi Mahmud
ORCID: 0000-0003-1604-8626
15
Learn Han Lee
16
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
Anahtar Kelimeler
anticancer activity
apoptosis
bioactive compound
pharmacodynamic action
Kurumlar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
Faculty of Science, Ibn Tofail University
Kenitra Morocco
Ibn Sina Hospital, Agdal Rabat
Agdal Rabat Morocco
Kyung Hee University
Seoul South Korea
Monash University Malaysia
Bandar Sunway Malaysia
Prokhorov General Physics Institute of the Russian Academy of Sciences
Moscow Russian Federation
Russian State Agrarian University - Moscow Timiryazev Agricultural Academy
Moscow Russian Federation
Selçuk Üniversitesi
Selçuklu Turkey
The John Curtin School of Medical Research
Canberra Australia
The University of Jordan
Amman Jordan
Universidade de Vigo
Vigo Spain
Université Cadi Ayyad
Marakech Morocco
Université Sidi Mohamed Ben Abdellah
Fez Morocco
V. M. Gorbatov Federal Research Center for Food Systems
Moscow Russian Federation
Metrikler
12
Atıf
16
Yazar
4
Anahtar Kelime