Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Evaluating the phyto-complexity and poly-pharmacology of spices: The case of Aframomum melegueta K. Schum (Zingiberaceae)
Food Bioscience · Ekim 2022
YÖKSİS Kayıtları
Evaluating the phyto-complexity and poly-pharmacology of spices: The case of Aframomum melegueta K. Schum (Zingiberaceae)
Food Biosicence · 2022 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
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Makale Bilgileri
Dergi
Food Bioscience
ISSN22124292
Yayın TarihiEkim 2022
Cilt / Sayfa49
Scopus ID2-s2.0-85135724983
Özet
The seeds of Aframomum melegueta K. Schum (grains of paradise, Zingiberaceae) are used as a common spice in African countries and a fine condiment in the European cuisine. In this study, we evaluated the phytochemical profile of various seed extracts of A. melegueta as well as their antimicrobial, antioxidant and enzyme inhibitory effects. In total, 25 diarylheptanoids, five gingerol derivatives and nine phenolic/organic acids were tentatively annotated in A. melegueta by liquid chromatography hyphenated with high resolution tandem mass spectrometry (LC-HRMS/MS). A. melegueta showed a moderate inhibitory activity against different human pathogenic microbial strains, with H. pylori the most sensitive microorganism. A strong antioxidant and enzyme inhibitory potential was shown in various radical scavenging, reducing and chelating assays as well as in cholinesterase, tyrosinase and glucosidase assays. Several specialized metabolites from A. melegueta (diarylheptanoids, gingerols) were shown to be directly linked with the investigated antioxidant and enzyme inhibitory activities, as evaluated through the correlation analysis. In addition, two diarylheptanoids (one heptan-3-ol and one heptan-3,5-diol) displayed the strongest binding to acetylcholinesterase (AChE) via multiple H-bonds, a couple of π-π interactions and van der Waals interactions all over the catalytic channel of the enzyme, as evidenced by the molecular docking study. Overall, our work brings new contributions to the phyto-complexity and poly-pharmacology of spices from genus Aframomum than can find future applications in pharmaceutical, nutraceutical or cosmeceutical industry.
Yazarlar (7)
1
Simon Vlad Luca
ORCID: 0000-0001-8785-249X
2
Adriana Trifan
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Kouadio Ibrahime Sinan
5
Abdullahi Ibrahim Uba
6
Izabela Korona-Glowniak
ORCID: 0000-0003-1634-0387
7
Krystyna Skalicka-Wozniak
Anahtar Kelimeler
Aframomum melegueta
Gingerols
Helicobacter
Spices
Zingiberaceae
Kurumlar
Kadir Has Üniversitesi
Istanbul Turkey
Medical University of Lublin
Lublin Poland
Selçuk Üniversitesi
Selçuklu Turkey
Technische Universität München
Munich Germany
Universitatea de Medicina si Farmacie Grigore T. Popa din Iasi
Iasi Romania
Scimago Dergi (ISSN Eşleşmesi)
Food Bioscience
Q1
SJR Skoru1,119
H-Index94
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Biochemistry (Q1)
Food Science (Q1)
Metrikler
11
Atıf
7
Yazar
5
Anahtar Kelime