“Smart Extraction Chain” with Green Solvents: Extraction of Bioactive Compounds from Picea abies Bark Waste for Pharmaceutical, Nutraceutical and Cosmetic Uses

Molecules · Ekim 2022

Makale Bilgileri

DergiMolecules

Yayın TarihiEkim 2022

Cilt / Sayfa27

DOI10.3390/molecules27196719

Scopus ID2-s2.0-85139957171

Erişim🔓 Açık Erişim

Özet Secondary metabolites from the sawmill waste Picea abies bark were extracted using an innovative two-step extraction that includes a first step with supercritical CO2 (SCO2) and a second step using green solvents, namely ethanol, water, and water ethanol mixture. Maceration (M), ultrasound assisted extraction (UAE) and microwave assisted extraction (MAE) techniques were applied in the second step. A total of nineteen extract were obtained and yield were compared. Bark extracts were characterized by LC-DAD-MSn and classes of compounds were quantified as abietane derivatives, piceasides, flavonoids, and phenolics to compare different extractions. Obtained extracts were studied by in vitro assay to evaluate potential pharmaceutical, nutraceutical and cosmetic uses assessing the antioxidant activity as well as the inhibitory activity on target enzymes. Results show that the “smart extraction chain” is advantageous in term of yield of extraction and phytoconstituent concentration. SCO2 extract, presenting a unique composition with a large amount of abietane derivatives, exerted the best activity for amylase inhibition compared to the other extracts.

Yazarlar (9)

Stefania Sut

Erica Maccari

Gokhan Zengin

ORCID: 0000-0001-6548-7823

Irene Ferrarese

Francesca Loschi

ORCID: 0000-0001-6068-6401

Marta Faggian

Bertoni Paolo

Nicola De Zordi

Stefano Dall'Acqua

Anahtar Kelimeler

antioxidant enzyme inhibition assays green extraction microwave assisted extraction Picea abies bark supercritical CO 2 ultrasound assisted extraction