Scopus
🔓 Açık Erişim
The Antioxidant and Enzyme Inhibitory Potential of n-Hexane-Extracted Oils Obtained from Three Egyptian Cultivars of the Golden Dewdrop Duranta erecta Linn. Supported by Their GC-MS Metabolome Analysis and Docking Studies
Antioxidants · Ekim 2022
Makale Bilgileri
DergiAntioxidants
Yayın TarihiEkim 2022
Cilt / Sayfa11
Scopus ID2-s2.0-85140473530
Erişim🔓 Açık Erişim
Özet
Duranta erecta Linn. has a longstanding history for use in folk remedy for several disorders. Its hydroalcoholic extract has been investigated intensely in the treatment of many ailments, but to date very few data are presented to explain the pharmacological use of its oil. In this study, the chemical profiles of the leaf oils extracted from three Egyptian Duranta erecta cultivars, namely ‘Green’, ‘Golden edge’, and ‘Variegata’ are traced using GC-MS analysis. D. erecta ‘Green’ showed predominance of vitamin E (22.7%) and thunbergol (15%) whereas D. erecta ‘Golden edge’ and ‘Variegata’ contained tetratetracontane as a major component in their oils. The highest phenolic and flavonoid contents, displayed as gallic acid and rutin equivalents per gram oil, respectively, were observed in the ‘Golden edge’ and ‘Variegata’ cultivars, which was reflected by their strong DPPH and ABTS scavenging activities as well as the highest reducing power in both CUPRAC and FRAP assays. D. erecta ‘Green’ displayed better metal chelating potential, which may be attributed to its content of vitamin E. All cultivars showed similar enzyme inhibitory profiles. The best inhibition of α-glucosidase and α-amylase was observed by D. erecta ‘Green’. In silico studies of the major constituents docked on the active sites of the target enzymes NADPH oxidase, amylase, glucosidase, butyrylcholinesterase, and tyrosinase revealed high binding scores, which justified the biological activities of the tested oils.
Yazarlar (7)
1
Shaimaa Fayez
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Sara T. Al-Rashood
4
Mahmoud A. El Hassab
ORCID: 0000-0002-6795-4816
5
Wagdy M. Eldehna
ORCID: 0000-0001-6996-4017
6
Stefano Dall'Acqua
7
Omayma A. Eldahshan
ORCID: 0000-0002-0972-0560
Anahtar Kelimeler
antioxidant activity
Duranta erecta
enzyme inhibitory effect
GC-MS profiling
in-silico studies
Kurumlar
Ain Shams University
Cairo Egypt
College of Pharmacy
Riyadh Saudi Arabia
Faculty of Pharmacy
Kafr el-Sheikh Egypt
Faculty of Pharmacy - Ain Shams University
Cairo Egypt
Field of Pharmacy
Ras Sedr Egypt
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Padova
Padua Italy
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime