Scopus
🔓 Açık Erişim
Bioactive Components and Health Potential of Endophytic Micro-Fungal Diversity in Medicinal Plants
Antibiotics · Kasım 2022
Makale Bilgileri
DergiAntibiotics
Yayın TarihiKasım 2022
Cilt / Sayfa11
Scopus ID2-s2.0-85141697434
Erişim🔓 Açık Erişim
Özet
The endophytic fungi that reside inside medicinal plants have the potential to produce various pharmaco-potential bioactive compounds. The endophytic fungi Graminicolous helminthosporium, Bipolaris australiensis and Cladosporium cladosporioides were isolated from different medicinal plants. The GC-MS analysis of intra- and extracellular products of endophytic fungi revealed the presence of various bioactive metabolites, such as Anthracene, Brallobarbital, Benzo [h] quinolone, Ethylacridine, 2-Ethylacridine, Cyclotrisiloxane, 5 methyl 2 phenylindolizine, and 1,4-Cyclohexadien-1-one, etc. The phytochemical composition analysis of endophytic fungus extracts also revealed the presence of flavonoids, phenols, saponins, carbohydrates, glycosides, and proteins. The intra- and extracellular endophytic extracts exhibited strong antibacterial and antioxidant activity, which was screened with the agar-well diffusion method and DPPH, H2O2, and nitric oxide scavenging activity, respectively. The bioactive compounds identified in the endophytic extracts from GC-MS profiling served as ligands for molecular-docking analysis to investigate the anticancer potential against non-small cell lung carcinoma receptor EGFR. Molecular docking results showed that compounds, such as Brallobarbital, and 5 methyl 2 phenylindolizine had the lowest E- min values, which suggests that these compounds could be used in anticancer drug development. Thus, the isolated endophytic fungal species can be used to produce various bioactive compounds that could be used in novel drug development from natural sources and reduce the environmental burden of synthetic chemical drugs.
Yazarlar (10)
1
Sundaram Muthukrishnan
2
Paranivasakam Prakathi
3
Thangavel Sivakumar
4
Muthu Thiruvengadam
5
Bindhu Jayaprakash
6
Baskar Venkidasamy
ORCID: 0000-0002-3888-7079
7
Maksim Rebezov
8
Marina Derkho
ORCID: 0000-0003-3818-0556
9
Gokhan Zengin
ORCID: 0000-0001-6548-7823
10
Mohammad Ali Shariati
ORCID: 0000-0001-9376-5771
Anahtar Kelimeler
antibacterial
antioxidant
bioactive compounds
entophytic fungi
FTIR
GC-MS
molecular docking
Kurumlar
Ayya Nadar Janaki Ammal College
Sivakasi India
Konkuk University
Seoul South Korea
Moscow State University of Technologies and Management
Moscow Russian Federation
Russian State Agrarian University - Moscow Timiryazev Agricultural Academy
Moscow Russian Federation
Saveetha Dental College And Hospitals
Chennai India
Selçuk Üniversitesi
Selçuklu Turkey
South Ural State Agrarian University
Troitsk Russian Federation
Sri Shakthi Institute of Engineering & Technology
Coimbatore India
V. M. Gorbatov Federal Research Center for Food Systems
Moscow Russian Federation
Metrikler
11
Atıf
10
Yazar
7
Anahtar Kelime