Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Exploring the Artemisia Genus: An Insight into the Phytochemical and Multi-Biological Potential of A. campestris subsp. lednicensis (Spreng.) Greuter & Raab-Straube
Plants · Kasım 2022
YÖKSİS Kayıtları
Exploring the Artemisia Genus: An Insight into the Phytochemical and Multi-Biological Potential of A. campestris subsp. lednicensis (Spreng.) Greuter & Raab-Straube
Plants · 2022 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiPlants
Yayın TarihiKasım 2022
Cilt / Sayfa11
Scopus ID2-s2.0-85141866639
Erişim🔓 Açık Erişim
Özet
The Artemisia L. genus includes over five hundred species with great economic and medicinal properties. Our study aimed to provide a comprehensive metabolite and bioactivity profile of Artemisia campestris subsp. lednicensis (Spreng.) Greuter & Raab-Straube collected from north-eastern Romania. Liquid chromatography with tandem high-resolution mass spectrometry (LC-HRMS/MS) analysis of different polarity extracts obtained from the aerial parts led to the identification of twelve flavonoids, three phenolic acids, two sesquiterpene lactones, two fatty acids, one coumarin, and one lignan. The antioxidant and enzyme inhibitory properties were shown in the DPPH (0.71–213.68 mg TE/g) and ABTS (20.57–356.35 mg TE/g) radical scavenging, CUPRAC (38.56–311.21 mg TE/g), FRAP (121.68–202.34 mg TE/g), chelating (12.88–22.25 mg EDTAE/g), phosphomolybdenum (0.92–2.11 mmol TE/g), anti-acetylcholinesterase (0.15–3.64 mg GALAE/g), anti-butyrylcholinesterase (0–3.18 mg GALAE/g), anti-amylase (0.05–0.38 mmol ACAE/g), anti-glucosidase (0.43–2.21 mmol ACAE/g), and anti-tyrosinase (18.62–48.60 mg KAE/g) assays. At 100 μg/mL, Artemisia extracts downregulated the secretion of tumor necrosis factor (TNF)-α in a lipopolysaccharide (LPS)-stimulated human neutrophil model (29.05–53.08% of LPS+ control). Finally, the Artemisia samples showed moderate to weak activity (minimum inhibitory concentration (MIC) > 625 mg/L) against the seventeen tested microbial strains (bacteria, yeasts, and dermatophytes). Overall, our study shows that A. campestris subsp. lednicensis is a promising source of bioactives with putative use as food, pharmaceutical and cosmetic ingredients.
Yazarlar (8)
1
Adriana Trifan
2
Monika E. Czerwińska
3
Constantin Mardari
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Kouadio Ibrahime Sinan
6
Izabela Korona-Glowniak
ORCID: 0000-0003-1634-0387
7
Krystyna Skalicka-Wozniak
8
Simon Vlad Luca
ORCID: 0000-0001-8785-249X
Anahtar Kelimeler
anti-enzymatic
antioxidant
flavonoids
LC-HRMS/MS
pro-inflammatory cytokines
wormwood
Kurumlar
Botanic Garden “Anastasie Fatu”
Iasi Romania
Medical University of Lublin
Lublin Poland
Medical University of Warsaw
Warsaw Poland
Selçuk Üniversitesi
Selçuklu Turkey
Technische Universität München
Munich Germany
Universitatea de Medicina si Farmacie Grigore T. Popa din Iasi
Iasi Romania
Metrikler
6
Atıf
8
Yazar
6
Anahtar Kelime