Scopus
🔓 Açık Erişim
Inhibition of obesity through alterations of C/EBP- α gene expression by gum Arabic in mice with a high-fat feed diet
Carbohydrate Polymer Technologies and Applications · Aralık 2022
Makale Bilgileri
DergiCarbohydrate Polymer Technologies and Applications
Yayın TarihiAralık 2022
Cilt / Sayfa4
Scopus ID2-s2.0-85133357480
Erişim🔓 Açık Erişim
Özet
Obesity is a metabolic disease associated with high morbidity and mortality worldwide. Previously we showed that Gum Arabic (GA) inhibited obesity in fed with diet-induced obesity. However, the mechanism underlying the mode of action is not fully elucidated. Here we aimed to identify the effects of GA on CCAAT-enhancer-binding protein- α (C/EBP- α) in mouse-fed diet-induced obesity. Thirty female CD-1 mice 90 days old were randomly divided into three groups (n=10). Mice were fed either a regular diet (control), a high-fat diet (HFD), or a high-fat diet containing 10% w/w GA (HFD+GA) for 15 weeks. Body weights, visceral adipose tissue (VAT), plasma lipid, blood glucose, plasma insulin, adiponectin, and leptin levels were measured. In addition, 11 β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and C/EBP- α gene mRNA expressions were measured, and 11β-HSD1 as well. Supplementation of GA significantly (P < 0.05) decreased body weight gain and VAT associated with decreases in blood glucose, total cholesterol LDL, and increased HDL concentrations. Likewise, administration of GA significantly (P < 0.05) decreased plasma Corticosterone (CORT) and leptin concentrations, whereas increased adiponectin compared to the control and HFD groups. In addition, GA administration significantly (P < 0.05) reduced the abundance of both hepatic 11β-HSD1 and C/EBP- α gene mRNA expression compared to the control and HFD groups. Supplementation of GA significantly (P < 0.05) down-regulated hepatic 11β-HSD1 protein expression compared to control and HFD groups. These findings indicate that GA consumption may be useful to prevent obesity through suppression of C/EBP- α gene expression.
Yazarlar (7)
1
Abdelkareem A. Ahmed
ORCID: 0000-0003-1524-0392
2
Hassan H. Musa
3
Mohammed Elmujtba Adam Essa
4
Adriano Mollica
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Hussain Ahmad
7
Saber Y. Adam
Anahtar Kelimeler
C/EBP- α gene
Gum arabic
High-fat feed diet
Mice
Obesity
Kurumlar
Botswana University of Agriculture and Natural Resources
Gaborone Botswana
Darfur University College
Nyala Sudan
Medical and Cancer Research Institute
Nyala Sudan
Selçuk Üniversitesi
Selçuklu Turkey
The Islamia University of Bahawalpur
Bahawalpur Pakistan
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Nyala
Nyala Sudan
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime