Scopus
🔓 Açık Erişim
Silviridoside: A New Triterpene Glycoside from Silene viridiflora with Promising Antioxidant and Enzyme Inhibitory Potential
Molecules · Aralık 2022
Makale Bilgileri
DergiMolecules
Yayın TarihiAralık 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85144480992
Erişim🔓 Açık Erişim
Özet
A new triterpene glycoside, silviridoside, was isolated from the aerial parts of Silene viridiflora (Caryophyllaceae) using different chromatographic techniques. The structure of silviridoside was comprehensively elucidated as 3-O-β-D-galacturonopyranosyl-quillaic acid 28-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-fucopyranosyl ester by one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HR-MS). Silviridoside showed promising antioxidant activity in different antioxidant assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) (2.32 mg TE/g), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (1.24 mg TE/g), cupric-reducing antioxidant capacity (CUPRAC) (9.59 mg TE/g), ferric-reducing antioxidant power (FRAP) (5.13 mg TE/g), phosphomolybdenum (PHD) (0.28 mmol TE/g), and metal-chelating (MCA) (6.62 mg EDTA/g) assays. It exhibited a good inhibitory potential on acetylcholinesterase (AChE) (2.52 mg GALAE/g), butyrylcholinesterase (BChE) (7.16 mg GALAE/g), α-amylase (0.19 mmol ACAE/g), α-glucosidase (1.21 mmol ACAE/g), and tyrosinase (38.83 mg KAE/g). An in silico evaluation of the pharmacodynamic, pharmacokinetic, and toxicity properties of silviridoside showed that the new compound exhibited reasonable pharmacodynamic and pharmacokinetic properties without any mutagenic effect, but slight toxicity. Thus, it could be concluded that silviridoside could act as a promising lead drug for pharmaceutical and nutraceutical developments to combat oxidative stress and various disorders, but a future optimization is necessary.
Yazarlar (8)
1
Markhabo M. Makhmudova
2
Markus Bacher
ORCID: 0000-0002-4307-4849
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Thomas Rosenau
ORCID: 0000-0002-6636-9260
5
Fadia S. Youssef
6
Diena M. Almasri
7
Sameh S. Elhady
ORCID: 0000-0003-3799-0581
8
Nilufar Z. Mamadalieva
ORCID: 0000-0003-1756-3638
Anahtar Kelimeler
ADME/TOPKAT
antioxidant
drug discovery
enzyme inhibitor
Silene viridiflora
silviridoside
sustainability of natural resources
triterpene glycoside
Kurumlar
BOKU University
Vienna Austria
Faculty of Pharmacy - Ain Shams University
Cairo Egypt
King Abdulaziz University
Jeddah Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
S. Yu. Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences
Tashkent Uzbekistan