Scopus
🔓 Açık Erişim
Inhibitory Potential of Chromene Derivatives on Structural and Non-Structural Proteins of Dengue Virus
Viruses · Aralık 2022
Makale Bilgileri
DergiViruses
Yayın TarihiAralık 2022
Cilt / Sayfa14
Scopus ID2-s2.0-85144481365
Erişim🔓 Açık Erişim
Özet
Dengue fever is a mosquito-borne viral disease that has become a serious health issue across the globe. It is caused by a virus of the Flaviviridae family, and it comprises five different serotypes (DENV-1 to DENV-5). As there is no specific medicine or effective vaccine for controlling dengue fever, there is an urgent need to develop potential inhibitors against it. Traditionally, various natural products have been used to manage dengue fever and its co-morbid conditions. A detailed analysis of these plants revealed the presence of various chromene derivatives as the major phytochemicals. Inspired by these observations, authors have critically analyzed the anti-dengue virus potential of various 4H chromene derivatives. Further, in silico, in vitro, and in vivo reports of these scaffolds against the dengue virus are detailed in the present manuscript. These analogues exerted their activity by interfering with various stages of viral entry, assembly, and replications. Moreover, these analogues mainly target envelope protein, NS2B-NS3 protease, and NS5 RNA-dependent RNA polymerase, etc. Overall, chromene-containing analogues exerted a potent activity against the dengue virus and the present review will be helpful for the further exploration of these scaffolds for the development of novel antiviral drug candidates.
Yazarlar (12)
1
Babitha Thekkiniyedath Dharmapalan
2
Raja Biswas
3
Sathianarayanan Sankaran
4
Baskar Venkidasamy
ORCID: 0000-0002-3888-7079
5
Muthu Thiruvengadam
6
Ginson George
ORCID: 0000-0002-7131-2496
7
Maksim Rebezov
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
9
Monica Gallo
10
Domenico Montesano
ORCID: 0000-0002-8857-2091
11
Daniele Naviglio
ORCID: 0000-0001-5191-7669
12
Mohammad Ali Shariati
ORCID: 0000-0001-9376-5771
Anahtar Kelimeler
chromene
dengue virus
flavonoids
non-structural proteins
structural proteins
virus inhibitory potential
Kurumlar
Amrita Institute of Medical Sciences India
Kochi India
Amrita Vishwa Vidyapeetham University, Kochi
Kochi India
Karpagam Academy of Higher Education
Coimbatore India
Konkuk University
Seoul South Korea
Moscow State University of Technologies and Management
Moscow Russian Federation
Russian State Agrarian University - Moscow Timiryazev Agricultural Academy
Moscow Russian Federation
Saveetha Dental College And Hospitals
Chennai India
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Napoli Federico II
Naples Italy
Ural State Agrarian University
Yekaterinburg Russian Federation
Metrikler
3
Atıf
12
Yazar
6
Anahtar Kelime