Scopus
🔓 Açık Erişim
Phytochemical Compounds and Nanoparticles as Phytochemical Delivery Systems for Alzheimer’s Disease Management
Molecules · Aralık 2022
Makale Bilgileri
DergiMolecules
Yayın TarihiAralık 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85144549885
Erişim🔓 Açık Erişim
Özet
Alzheimer’s disease remains one of the most widespread neurodegenerative reasons for dementia worldwide and is associated with considerable mortality and morbidity. Therefore, it has been considered a priority for research. Indeed, several risk factors are involved in the complexity of the therapeutic ways of this pathology, including age, traumatic brain injury, genetics, exposure to aluminum, infections, diabetes, vascular diseases, hypertension, dyslipidemia, and obesity. The pathophysiology of Alzheimer’s disease is mostly associated with hyperphosphorylated protein in the neuronal cytoplasm and extracellular plaques of the insoluble β-amyloid peptide. Therefore, the management of this pathology needs the screening of drugs targeting different pathological levels, such as acetylcholinesterase (AchE), amyloid β formation, and lipoxygenase inhibitors. Among the pharmacological strategies used for the management of Alzheimer’s disease, natural drugs are considered a promising therapeutic strategy. Indeed, bioactive compounds isolated from different natural sources exhibit important anti-Alzheimer effects by their effectiveness in promoting neuroplasticity and protecting against neurodegeneration as well as neuroinflammation and oxidative stress in the brain. These effects involve different sub-cellular, cellular, and/or molecular mechanisms, such as the inhibition of acetylcholinesterase (AchE), the modulation of signaling pathways, and the inhibition of oxidative stress. Moreover, some nanoparticles were recently used as phytochemical delivery systems to improve the effects of phytochemical compounds against Alzheimer’s disease. Therefore, the present work aims to provide a comprehensive overview of the key advances concerning nano-drug delivery applications of phytochemicals for Alzheimer’s disease management.
Yazarlar (11)
1
Saad Bakrim
2
Sara Aboulaghras
3
Naoual El Menyiy
4
Nasreddine El Omari
5
Hamza Assaggaf
ORCID: 0000-0001-5563-9491
6
Learn Han Lee
7
Domenico Montesano
ORCID: 0000-0002-8857-2091
8
Monica Gallo
9
Gokhan Zengin
ORCID: 0000-0001-6548-7823
10
Yusra AlDhaheri
11
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
Anahtar Kelimeler
Alzheimer’s disease
bioactive compound
nano-drugs
neuroinflammation
Kurumlar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
Monash University Malaysia
Bandar Sunway Malaysia
National Agency of Medicinal and Aromatic Plants
Taounate Morocco
Selçuk Üniversitesi
Selçuklu Turkey
Umm Al-Qura University
Makkah Saudi Arabia
United Arab Emirates University
Al Ain United Arab Emirates
Università degli Studi di Napoli Federico II
Naples Italy
Université Ibn Zohr
Agadir Morocco
Metrikler
8
Atıf
11
Yazar
4
Anahtar Kelime