Scopus
🔓 Açık Erişim
Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action
Frontiers in Pharmacology · Aralık 2022
Makale Bilgileri
DergiFrontiers in Pharmacology
Yayın TarihiAralık 2022
Cilt / Sayfa13
Scopus ID2-s2.0-85145451622
Erişim🔓 Açık Erişim
Özet
Sepsis is a severe inflammatory response to systemic infection and is a threatening cause of death in intensive care units. In recent years, a number of studies have been conducted on the protective effect of natural products against sepsis-induced organ injury. However, a comprehensive review of these studies indicating the mechanisms of action of the bioactive compounds is still lacking. In this context, this review aimed to provide an updated analysis of the mechanism of action of plants’ secondary metabolites in the management of sepsis. Scopus, Science Direct, Google Scholar, and PubMed were searched from inception to July 2022. A variety of secondary metabolites were found to be effective in sepsis management including allicin, aloin, cepharanthine, chrysin, curcumin, cyanidin, gallic acid, gingerol, ginsenoside, glycyrrhizin, hesperidin, kaempferol, narciclasine, naringenin, naringin, piperine, quercetin, resveratrol, rosmarinic acid, shogaol, silymarin, sulforaphane, thymoquinone, umbelliferone, and zingerone. The protective effects exerted by these compounds can be ascribed to their antioxidant properties as well as induction of endogenous antioxidant mechanisms, and also via the downregulation of inflammatory response and reduction of biochemical and inflammatory markers of sepsis. These findings suggest that these secondary metabolites could be of potential therapeutic value in the management of sepsis, but human studies must be performed to provide strength to their potential clinical relevance in sepsis-related morbidity and mortality reduction.
Yazarlar (5)
1
Mohamad Fawzi Mahomoodally
2
Muhammad Zakariyyah Aumeeruddy
3
Lesetja Legoabe
4
Stefano Dall'Acqua
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
inflammation
phytochemicals
plants
secondary metabolites
sepsis
Kurumlar
Duy Tan University
Da Nang Viet Nam
North-West University
Potchefstroom South Africa
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Padova
Padua Italy
University of Mauritius
Reduit Mauritius
Metrikler
8
Atıf
5
Yazar
5
Anahtar Kelime