Scopus
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Neuroprotective Potential of Biflavone Ginkgetin: A Review
Life · Şubat 2023
YÖKSİS Kayıtları
Neuroprotective Potential of Biflavone Ginkgetin: A Review
Life-Basel · 2023 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiLife
Yayın TarihiŞubat 2023
Cilt / Sayfa13
Scopus ID2-s2.0-85148873941
Erişim🔓 Açık Erişim
Özet
Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkgo (Ginkgo biloba L.). Later, its occurrence was discovered in more than 20 different plant species, most of which are known for their use in traditional medicine. Herein we have summarized the data on the neuroprotective potential of ginkgetin. There is evidence of protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Beneficial effects in ischemic strokes have been demonstrated in animal studies in which injection of ginkgetin before or after onset of the stoke showed protection from neuronal damage. AD protection has been the most studied to date. Possible mechanisms include inhibition of reactive oxygen species, inhibition of β-secretase, inhibition of Aβ fibril formation, amelioration of inflammation, and antimicrobial activity. Ginkgetin has also shown positive effects on the relief of PD symptoms in animal studies. Most of the available data are from in vitro or in vivo animal studies, where ginkgetin showed promising results, and further clinical studies should be conducted.
Yazarlar (4)
1
İrem Tatlı Çankaya
ORCID: 0000-0001-8531-9130
2
Hari Prasad Devkota
ORCID: 0000-0002-0509-1621
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Dunja Šamec
ORCID: 0000-0002-0600-6847
Anahtar Kelimeler
Alzheimer’s disease
biflavonoids
ginkgetin
ginkgo
neuroprotection
Kurumlar
Graduate School of Medical Sciences
Kumamoto Japan
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University North
Koprivnica Croatia
Metrikler
7
Atıf
4
Yazar
5
Anahtar Kelime