Scopus
YÖKSİS Eşleşti
Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches
Chemistry and Biodiversity · Nisan 2023
YÖKSİS Kayıtları
Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in vitro and in silico Approaches
Chemistry & Biodiversity · 2023 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiChemistry and Biodiversity
Yayın TarihiNisan 2023
Cilt / Sayfa20
Scopus ID2-s2.0-85150664088
Özet
Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual phenolic compounds, total phenolic and total flavonoid contents (HPLC/MS analysis), reducing power and metal chelating effects of four extracts obtained from A. elongatum (ethyl acetate (EA), methanol (MeOH), methanol/water (MeOH/water) and infusion). The inhibitory activity of the extracts were also determined against acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase enzymes. The MeOH/water extracts contained the highest amount of phenolic contents (28.85 mg GAE/g) while the highest total flavonoid content was obtained with MeOH extract (36.77 mg RE/g). MeOH/water demonstrated highest antioxidant activity against DPPH⋅ radical at 38.90 mg Trolox equivalent per gram. The infusion extract was the most active against ABTS+⋅ (133.08 mg TE/g). MeOH/water extract showed the highest reducing abilities with the CUPRAC value of 102.22 mg TE/g and the FRAP value of 68.50 mg TE/g. A strong metal chelating effect was observed with MeOH/water extract (35.72 mg EDTAE/g). The PBD values of the extracts ranged from 1.01 to 2.17 mmol TE/g. EA extract displayed the highest inhibitory activity against AChE (2.32 mg GALAE/g), BChE (3.80 mg GALAE/g), α-amylase (0.56 mmol ACAE/g) and α-glucosidase (9.16 mmol ACAE/g) enzymes. Infusion extract was the most active against tyrosinase enzyme with a value of 83.33 mg KAE/g. A total of 28 compounds were identified from the different extracts. The compounds present in the highest concentration were chlorogenic acids, 4-hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, isoquercitrin, delphindin 3,5-diglucoside, kaempferol-3-glucoside and hyperoside. The biological activities of A. elongatum extracts could be due to the presence of compounds such as gallic acid, chlorogenic acids, ellagic acid, epicatechin, catechin, kaempferol, 4-hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, quercetin, isoquercitrin, and hyperoside. Extracts of A. elongatum showed promising biological activities which warrants further investigations in an endeavor to develop biopharmaceuticals.
Yazarlar (13)
1
Mohamad Fawzi Mahomoodally
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Seebaluck Sandoram Roumita
4
Giovanni Caprioli
ORCID: 0000-0002-5530-877X
5
Ahmed M. Mustafa
6
Diletta Piatti
ORCID: 0009-0001-9590-5560
7
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
8
Gunes Ak
9
Ayşe Esra Karadağ
10
Asaad Khalid
11
Ashraf N. Abdalla
12
Abdullahi Ibrahim Uba
13
Fatih Demirci
Anahtar Kelimeler
Arum
bioactive agent
natural enzyme inhibitors
phenolic composition
Kurumlar
Anadolu Üniversitesi
Eskisehir Turkey
İstanbul Arel Üniversitesi
Istanbul Turkey
İstanbul Medipol Üniversitesi
Istanbul Turkey
Jazan University
Jizan Saudi Arabia
National Center for Research Sudan
Khartoum Sudan
North-West University
Potchefstroom South Africa
Saveetha Dental College And Hospitals
Chennai India
Selçuk Üniversitesi
Selçuklu Turkey
Umm Al-Qura University
Makkah Saudi Arabia
Università degli Studi di Camerino
Camerino Italy
University of Mauritius
Reduit Mauritius
Metrikler
4
Atıf
13
Yazar
4
Anahtar Kelime