Scopus
YÖKSİS Eşleşti
Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies
Sustainable Chemistry and Pharmacy · Haziran 2023
YÖKSİS Kayıtları
Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies
Sustainable Chemistry and Pharmacy · 2023 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies
Sustainable Chemistry and Pharmacy · 2023 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiSustainable Chemistry and Pharmacy
Yayın TarihiHaziran 2023
Cilt / Sayfa33
Scopus ID2-s2.0-85159574905
Özet
The plant species Opopanax hispidus is known in traditional Turkish medicine and nutrition. In addition to all the advantages that are known by the traditions of old generations, O. hispidus has been insufficiently examined, and its potential could be used in treatment in modern medicine and diet. In this paper, O. hispidus extracts obtained by conventional (maceration (MAC), and Soxhlet (SOX)) and contemporary (accelerated solvent extraction (ASE), homogenizer assisted extraction (HAE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), supercritical fluid extraction (SFE)) methods were examined in terms of their chemical composition and biological potential. The extract obtained by HAE extraction had the highest content of total phenolics and flavonoids (36.98 mg GAE/g and 15.04 mg RE/g, respectively). The highest antioxidant activity was recorded for HAE and ASE extracts. O. hispidus extracts achieved inhibitory activity against acetylcholinesterase (4.12–6.44 mg GALAE/g), tyrosinase (44.78–76.72 mg KAE/g), α-amylase (0.35–0.46 mmol ACAE/g), and α-glucosidase (1.67–1.77 mmol ACAE/g) enzymes. LC-MS technique was used for the quantitative analysis of the extracts, allowing the quantification of chlorogenic acid, neochlorogenic acid, and p-coumaric acid, rutin, luteolin, and kaempferol 3-O-glucoside as the most abundant phenolic components. Results suggested that the green extraction techniques for obtaining extracts that are rich in bioactive compounds have advantages compared to conventional extraction. Therefore, these extracts can be used as antioxidants, neuroprotective, antityrosinase, and antidiabetic agents while respecting the principles of sustainable development and green chemistry.
Yazarlar (7)
1
Aleksandra Cvetanović Kljakić
2
Alena Stupar
3
Milena Terzic
4
Jelena Božunović
5
Uroš Gašić
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
7
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
Anahtar Kelimeler
Green technique
Opopanax
Pharmaceuticals
Phenolics
Traditional extraction
Kurumlar
Institute of Food Technology in Novi Sad
Novi Sad Serbia
Selçuk Üniversitesi
Selçuklu Turkey
University of Belgrade
Belgrade Serbia
University of Novi Sad
Novi Sad Serbia
Metrikler
4
Atıf
7
Yazar
5
Anahtar Kelime