Scopus
🔓 Açık Erişim
Food-inspired peptides from spinach Rubisco endowed with antioxidant, antinociceptive and anti-inflammatory properties
Food Chemistry: X · Haziran 2023
Makale Bilgileri
DergiFood Chemistry: X
Yayın TarihiHaziran 2023
Cilt / Sayfa18
Scopus ID2-s2.0-85151785780
Erişim🔓 Açık Erişim
Özet
Rubiscolin-6 (amino acid sequence: YPLDLF) is a selective δ-opioid receptor peptide isolated from spinach Rubisco. Its synthetic analogue, peptide YPMDIV is the most potent described so far for its increased opioid activity, thus in this work it was considered as lead compound for the design of twelve new analogues e.g. LMAS1-12. Firstly all the novel compounds have been tested for their antinociceptive and anti-inflammatory capacity in vitro and in vivo in order to evaluate their ability to maintain or loss the original activity. Among them peptides LMAS5-8 gave the best results, thus their antioxidant properties have been investigated along with their enzymatic inhibitory ability. Peptide LMAS6 shows a strong antioxidant (154.25 mg TE/g CUPRAC) and inhibitor activity on tyrosinase (84.49 mg KAE/g), indicating a potential role in food industry as anti-browning agent, while peptides LMAS5 and LMAS7 possess a modest cholinesterase inhibitory activity suggesting a conceivable use for nutraceuticals production.
Yazarlar (10)
1
Lorenza Marinaccio
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Stefano Pieretti
4
Paola Minosi
5
Edina Szucs
6
Sandor Benyhe
7
Ettore Novellino
8
Domiziana Masci
9
Azzurra Stefanucci
10
Adriano Mollica
Anahtar Kelimeler
Anti-browning agent
Antioxidants
Nutraceuticals
Rubisco
Rubiscolin-6
Kurumlar
Istituto Superiore Di Sanita
Rome Italy
NGN Healthcare
Torrette Italy
Selçuk Üniversitesi
Selçuklu Turkey
Szegedi Biológiai Kutatóközpontjának
Szeged Hungary
Università Cattolica del Sacro Cuore, Campus di Roma
Rome Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
19
Atıf
10
Yazar
5
Anahtar Kelime