Scopus
🔓 Açık Erişim
Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica
Plants · Ağustos 2023
Makale Bilgileri
DergiPlants
Yayın TarihiAğustos 2023
Cilt / Sayfa12
Scopus ID2-s2.0-85167409232
Erişim🔓 Açık Erişim
Özet
Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases.
Yazarlar (17)
1
Alessandra Acquaviva
2
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
3
Nilofar
4
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Lucia Recinella
7
Sheila Leone
8
Luigi Brunetti
9
Abdullahi Ibrahim Uba
10
Osman Guler
ORCID: 0000-0001-8225-1505
11
Mehmet Maruf Balos
12
Ugur Cakilcioglu
13
Luigi Menghini
ORCID: 0000-0002-7346-7395
14
Claudio Ferrante
15
Giustino Orlando
16
Maria Loreta Libero
ORCID: 0000-0002-8133-5691
17
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
Anahtar Kelimeler
anti-inflammatory
antioxidant
Nepeta italica
rosmarinic acid
Kurumlar
Faculté des Sciences Rabat
Rabat Morocco
İstanbul Arel Üniversitesi
Istanbul Turkey
Munzur University
Pertek Turkey
Sanlıurfa Provincial Directorate of National Education
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
12
Atıf
17
Yazar
4
Anahtar Kelime