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Scopus 🔓 Açık Erişim YÖKSİS DOI Eşleşti SJR Q3

Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies

Chemistry and Biodiversity · Eylül 2023

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YÖKSİS Kayıtları
Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies
Wiley · 2023 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential ofHaplophyllum sahiniiandH. vulcanicumExtracts
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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
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Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. GÖKHAN ZENGİN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Makale Bilgileri

Dergi Chemistry and Biodiversity
ISSN16121872
Yayın TarihiEylül 2023
Cilt / Sayfa20
DOI10.1002/cbdv.202300117
Scopus ID2-s2.0-85167359926
Erişim🔓 Açık Erişim
Özet Rhoifolin (apigenin-7-O-β-neohesperidoside) belongs to the class of flavonoids and was reported to exhibit anti-inflammatory, cytotoxic, antidiabetic, hepatoprotective, and cardioprotective activities. The current study presents the in-vitro evaluation of the antioxidative effects of rhoifolin by many assays, namely DPPH, CUPRAC, ABTS, phosphomolybdenum, and FRAP. Enzyme inhibitory potential was also evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase enzymes. While results revealed weak antioxidant activities for rhoifolin, the compound demonstrated some promising enzyme inhibitory effects against BChE (4.03 mg GALAE/g) and tyrosinase (7.44 mg KAE/g) but was not active on AChE. Regarding anti-diabetic enzymes, the compound was active on amylase but did not show any inhibition effect on glucosidase. In-silico molecular docking study was performed for rhoifolin on the active site of NADPH oxidase, BChE, and amylase enzymes to verify the observed enzyme inhibitory effect. Good binding affinities were observed for rhoifolin on all the docked enzymes, revealing numerous hydrogen bonds, carbon-hydrogen, van der Waals interactions. This is the first study to evaluate the enzyme inhibition potential of rhoifolin. We concluded that the increase in the degree of glycosylation might decrease the antioxidant abilities of flavonoids and that rhoifolin had moderate enzyme inhibition abilities to be investigated in future studies.

Yazarlar (4)

1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Nada M. Mostafa
3
Yasmin M. Abdelkhalek
4
Omayma A. Eldahshan
ORCID: 0000-0002-0972-0560

Anahtar Kelimeler

antioxidant enzyme Inhibition flavonoids molecular docking rhoifolin

Kurumlar

Faculty of Dentistry - Ain Shams University
Cairo Egypt
Faculty of Pharmacy - Ain Shams University
Cairo Egypt
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Chemistry and Biodiversity
Q3
SJR Skoru0,425
H-Index87
YayıncıWiley-Blackwell
ÜlkeUnited States
Biochemistry (Q3)
Bioengineering (Q3)
Chemistry (miscellaneous) (Q3)
Medicine (miscellaneous) (Q3)
Molecular Biology (Q4)
Molecular Medicine (Q4)
Dergi sayfasına git

Metrikler

14
Atıf
4
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

GZ
GÖKHAN ZENGİN
Prof. Dr.

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