Scopus
🔓 Açık Erişim
Impact of pomegranate juice on blood pressure: A systematic review and meta-analysis
Phytotherapy Research · Ekim 2023
Makale Bilgileri
DergiPhytotherapy Research
Yayın TarihiEkim 2023
Cilt / Sayfa37 · 4429-4441
Scopus ID2-s2.0-85165274410
Erişim🔓 Açık Erişim
Özet
Despite the importance of polyphenol-rich fruits in decreasing cardiovascular mortality, the impact of pomegranate juice (PJ) on blood pressure is still unclear. To determine the effect of PJ on blood pressure. PubMed, Scopus, ISI Web of Science, and Cochrane Library were searched comprehensively using relevant keywords. All studies using pomegranate juice alone were included although limited to human studies and the English language. A random-effects model and the generic inverse variance approach were used to determine quantitative data synthesis. Meta-analysis of 14 clinical trials (n = 573 individuals) demonstrated a reduction in systolic BP (SBP) with pomegranate juice (MD: −5.02 mmHg, 95% CI: −7.55 to −2.48, p < 0.001). Effect of study duration showed pomegranate juice intake ≤2 months significantly decreased SBP (MD: −4.59 mmHg, 95% CI: −7.10 to −2.08, p < 0.001) and DBP (MD: −2.94 mmHg, 95% CI: −5.25 to −0.63, p = 0.01). Consumption of ≤300 mL pomegranate juice daily reduced SBP (MD: −6.11 mmHg, 95% CI: −9.22 to −3.00, p < 0.001). Counterintuitively, >300 mL/day of pomegranate juice showed no effect on SBP (MD: −3.28 mmHg, 95% CI: −6.85 to 0.27, p = 0.07) but a significant DBP reduction occurred (MD: −3.10 mmHg, 95% CI: −5.74 to −0.47, p = 0.02). Meta-regression showed that the SBP-lowering effect of pomegranate juice was associated with the dose of supplementation (p < 0.001). Pomegranate juice appeared to decrease SBP and DBP in a dose-dependent manner, but the benefit was lost after 2 months of pomegranate juice intake.
Yazarlar (6)
1
Fatemeh Ghaemi
ORCID: 0000-0002-7414-3288
2
Maryam Emadzadeh
ORCID: 0000-0002-1526-3765
3
Stephen L. Atkin
ORCID: 0000-0002-5887-7257
4
Tannaz Jamialahmadi
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Amirhossein Sahebkar
Anahtar Kelimeler
blood pressure
hypertension
meta-analysis
P. granatum
pomegranate
Kurumlar
Ghaem Educational, Research and Treartment Center
Mashhad Iran
Mashhad University of Medical Sciences
Mashhad Iran
Royal College of Surgeons in Ireland Medical University of Bahrain
Muharraq Bahrain
School of Pharmacy
Mashhad Iran
Selçuk Üniversitesi
Selçuklu Turkey
UWA Medical School
Perth Australia
Metrikler
3
Atıf
6
Yazar
5
Anahtar Kelime