Scopus
🔓 Açık Erişim
Neuroprotective effect of Potentilla reptans L. root in the rat brain global ischemia/reperfusion model
Archiv der Pharmazie · Kasım 2023
Makale Bilgileri
DergiArchiv der Pharmazie
Yayın TarihiKasım 2023
Cilt / Sayfa356
Scopus ID2-s2.0-85168900906
Erişim🔓 Açık Erişim
Özet
Stroke is the most common cause of death among neurological diseases. The protective effects of Potentilla reptans L. include antioxidative, anti-inflammatory, and antiapoptotic effects. In this study, the brain protection and beta-amyloid effects of P. reptans root extract were investigated in the rat brain ischemia/reperfusion (IR) model. Forty male Wistar rats were randomly divided into five groups (n = 8), including IR, sham, and three groups receiving P. reptans with concentrations of 0.025, 0.05, and 0.1 (g/kg/b.w.), which were injected daily for 7 days. For the IR model, the common carotid artery was occluded bilaterally for 8 min. All injections were intraperitoneal (IP). The shuttle box test was used to measure passive avoidance memory. Then the brain tissue was extracted for the histological examination of neuron counts and β-amyloid plaques using a morphometric technique, and finally, Statistical Package for the Social Sciences software was used for statistical analysis of the data. Pretreatment with P. reptans improved memory impairment. Also, by examining the tissues of the CA1, CA3, and dentate gyrus areas of the hippocampus, it was observed that the number of plaques in the groups receiving P. reptans extract was reduced compared to the IR group, especially at the concentration of 0.05 g/kg/b.w. Also, P. reptans improved the number of neurons at all concentrations, in which the concentration of 0.05 g/kg/b.w. showed more effective therapeutic results. Taken together, we found that P. reptans root extract has beneficial effects on memory impairment, neuronal loss, and β-amyloid accumulation.
Yazarlar (6)
1
Soraya Noorgaldi
2
Hamzeh Badeli Sarkala
ORCID: 0000-0002-4264-1071
3
Ayesheh Enayati
4
Vahid Khori
ORCID: 0000-0002-4672-9732
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Mehrdad Jahanshahi
Anahtar Kelimeler
amyloid plaque
hippocampus
neurons
Potentilla reptans root
stroke
Kurumlar
Golestan University of Medical Sciences
Gorgan Iran
School of Medicine (IUMS)
Tehran Iran
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
6
Yazar
5
Anahtar Kelime