Scopus
Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC-MS/MS and Its In-Depth Antioxidant and Enzyme Inhibitory Activities
Chemistry and Biodiversity · Aralık 2023
Makale Bilgileri
DergiChemistry and Biodiversity
Yayın TarihiAralık 2023
Cilt / Sayfa20
Scopus ID2-s2.0-85177057804
Özet
The importance of bioactive plant species in the scientific world is increasing day by day. The relationship between health and traditional-modern life, promotes the creation of new value-added natural products. This is the first research to conduct a bioactivity and chemical composition analysis of Campanula baskilensis species, which belongs to the medicinally important genus Campanula L (Campanulaceae). The aim of the current study is to quantitatively investigate the phytochemical contents of aerial and root parts of different C. baskilensis extracts (ethanol, methanol, and water) by LC-MS/MS and to evaluate their total phenolic and flavonoid contents, antioxidant and enzyme inhibitory activities. Remarkably, LC-MS/MS results revealed that, high amounts of quinic acid (53.6 mg/g aerial-MeOH extract), fumaric acid (6.3 mg/g aerial-H2O extract, 2.5 mg/g root-H2O extract), protocatechuic acid (11.4 mg/g aerial-H2O extract), vanillic acid (1.4 mg/g aerial-EtOH extract), quercetin-3-O-rutinoside (rutin) (2.3 mg/g aerial-EtOH extract), hesperetin 7-rutinoside (hesperidin) (2.0 mg/g aerial-EtOH extract), kaempferol-3-O-rutinoside (nicotiflorin) (5.5 mg/g aerial-EtOH extract) were detected in the extracts of the species. Considering the bioactivity tests performed on C. baskilensis extracts, aerial-H2O extract showed significant activity in all antioxidant assays. However, ethanol extracts of root and aerial parts exhibited the highest activities in all enzyme inhibitory tests.
Yazarlar (6)
1
Mustafa Abdullah Yılmaz
2
Oguz Cakir
ORCID: 0000-0002-8006-2054
3
Ebubekir Izol
ORCID: 0000-0003-0788-4999
4
Abbas Tarhan
ORCID: 0000-0001-5196-3892
5
Lutfi Behcet
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
antioxidant
bioactivity
Campanula baskilensis
enzyme inhibition
LC-MS/MS
Kurumlar
Bingöl Üniversitesi
Bingol Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
6
Yazar
5
Anahtar Kelime