Scopus
YÖKSİS Eşleşti
UHPLC-ESI-QTOF-MS metabolite profiles of different extracts from Pelargonium endlicherianum parts and their biological properties based on network pharmacological approaches
Archiv der Pharmazie · Mayıs 2024
YÖKSİS Kayıtları
UHPLC-ESI-QTOF-MS metabolite profiles of different extracts from Pelargonium endlicherianum parts and their biological properties based on network pharmacological approaches
Archiv der Pharmazie · 2024 SCI-Expanded
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Makale Bilgileri
DergiArchiv der Pharmazie
Yayın TarihiMayıs 2024
Cilt / Sayfa357
Scopus ID2-s2.0-85184157104
Özet
In the present study, we aimed to investigate the chemical profiles and biological activities of different extracts (ethyl acetate, dichloromethane, ethanol, and water) of Pelargonium endlicherianum parts (aerial parts and roots). Free radical scavenging, reducing power, phosphomolybdenum, and metal chelating were assayed for antioxidant properties. To detect enzyme inhibitory properties, cholinesterase, amylase, glucosidase, and tyrosinase were chosen as target enzymes. The ethanol extract of the aerial parts contained higher amounts of total bioactive compounds (120.53 mg GAE/g-24.46 mg RE/g). The ethanol and water extracts of these parts were tentatively characterized by UHPLC-ESI-QTOF-MS and 95 compounds were annotated. In addition, the highest acetylcholiesterase (3.74 mg GALAE/g) and butyrylcholinesterase (3.92 mg GALAE/g) abilities were observed by the ethanol extract of roots. The water extract from aerial parts exhibited the most pronounced inhibitory effects on multiple cancer cell lines, especially A549 (IC50: 23.2 µg/mL) and HT-29 (IC50: 27.43 µg/mL) cells. Using network pharmacology, P. endlicherianum compounds were studied against cancer, revealing well-connected targets such as epidermal growth factor receptor (EGFR), phosphoinositide-3-kinase (PI3K), AKT, receptor tyrosine-protein kinase erbB-2, and growth factor receptor bound protein 2 (GRB2) with significant impact on cancer-related pathways. The results could open a new path from natural treasure to functional applications with P. endlicherianum and highlight a new study on other uninvestigated Pelargonium species.
Yazarlar (12)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Francisco Javier Leyva-Jiménez
3
Álvaro Fernández-Ochoa
4
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
5
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
6
Antonio Segura Carretero
7
Mohamad Fawzi Mahomoodally
8
Sathish Kumar M. Ponniya
9
Nilofar
10
Ismail Koyuncu
11
Ozgur Yuksekdag
12
María de la Luz Cádiz-Gurrea
Anahtar Kelimeler
antioxidant
enzyme inhibition
metabolite profiling
Pelargonium endlicherianum
Kurumlar
Duy Tan University
Da Nang Viet Nam
Faculté des Sciences Rabat
Rabat Morocco
Harran University, Faculty of Medicine
Sanliurfa Turkey
Pondicherry University
Puducherry India
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Castilla-La Mancha
Ciudad Real Spain
Universidad de Granada, Facultad de Ciencias
Granada Spain
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
2
Atıf
12
Yazar
4
Anahtar Kelime