Scopus
YÖKSİS Eşleşti
Multidirectional research for the therapeutic potential of Phlomoides molucelloides (Bunge) Salmaki: LC-MS/MS, antioxidant, enzyme inhibition, and antiproliferative characteristics
Process Biochemistry · Ağustos 2024
YÖKSİS Kayıtları
Multidirectional research for the therapeutic potential of Phlomoides molucelloides (Bunge) Salmaki: LC-MS/MS, antioxidant, enzyme inhibition, and antiproliferative characteristics
Process Biochemistry · 2024 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiProcess Biochemistry
Yayın TarihiAğustos 2024
Cilt / Sayfa143 · 302-314
Scopus ID2-s2.0-85193524232
Özet
Medicinal plants offer natural cures and inspire modern medicine's development. This study examined the antioxidant, enzyme-inhibitory, and antiproliferative activities of various extracts obtained from aerial and root fragments of Phlomoides molucelloides (Bunge) Salmaki. The extracts' overall phenolics, flavonoids, and compounds were defined using colorimetric and LC-MS/MS analyses. The highest total phenolic and flavonoid content was measured in the methanol and infusion extracts of the aerial fragments, with 102.21 mg RE/g and 51.33 mg GAE/g, respectively. Most compounds were defined as flavonoids, predominantly as apigenin and quercetin glycosides. Methanol, 70 % methanol, and infusion extracts from aerial parts had the highest antioxidant activity determined by DPPH, ABTS, CUPRAC, FRAP, metal chelation, and phosphomolybdenum analyses. Moreover, the methanol extract of the roots had the highest anti-acetylcholinesterase, anti-butyrylcholinesterase, and anti-glucosidase activities. The dichloromethane extracts of the roots displayed the highest anti-tyrosinase and anti-amylase activities. The antiproliferative activity of the extracts was investigated against MDA-MB-231, MCF-7, and HeLa cell lines. The lowest IC50 value (875.7 µg/mL) was computed for the methanol extract of the aerial part on the MCF-7 cell line at the 48th h. The findings showed that P. molucelloides extracts may offer a promising therapeutic approach due to their rich bioactive content.
Yazarlar (9)
1
Anfal Izaldeen Mutar Al Kateeb
2
Enis Fuat Tüfekci
3
Yasemin Celik Altunoglu
4
Mehmet Cengiz Baloglu
5
Nilufar Nilofar
6
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
7
József Jekő
8
Zoltán Cziáky
9
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
Antioxidant
Antiproliferative
Enzyme inhibition
Flavonoids
Phlomoides molucelloides (Bunge) Salmaki
Kurumlar
Kastamonu University
Kastamonu Turkey
Sabancı Üniversitesi
Tuzla Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Nyíregyháza
Nyíregyháza Hungary
Wasit University
Wasit Iraq