Scopus
🔓 Açık Erişim
Valorization of hydro-distillate of fruit peels of Citrus paradisi macfad. Cultivar. Foster: Chemical profiling, antioxidant evaluation and in vitro and in silico enzyme inhibition studies
Heliyon · Eylül 2024
Makale Bilgileri
DergiHeliyon
Yayın TarihiEylül 2024
Cilt / Sayfa10
Scopus ID2-s2.0-85201910576
Erişim🔓 Açık Erişim
Özet
The major commercial crops in Pakistan are citrus fruit trees, which are farmed extensively and serve as the country's principal source of foreign exchange. A local citrus plant, Citrus paradisi, variety Foster is famous for its valuable fruit and fruit juice, however, tons of peels of this fruit are thrown as waste, which otherwise can be utilized in formulating nutraceutical and cosmetics. In the present study, essential oil of fruit peels was obtained through hydro-distillation, which was then analyzed through GC-MS analysis and studied for its antioxidant and enzyme inhibition potential. GCMS analysis revealed the presence of several components; major were found to be limonene, α-terpineol, caryophyllene, δ-amorphene, elemol, γ-eudesoml, nootkatone and di-isooctyl phthalate. Although, the oil showed weak free radical inhibition, it was potentially active in CUPRAC, FRAP, phosphomolybdenum and metal chelating antioxidant assays. The oil also exhibited anti-glucosidase, anti-amylase activities and also exhibited potent inhibition of the enzyme tyrosinase, which makes it strong candidate for nutraceuticals and skin care products. The docking studies also substantiate our results and caryophyllene, γ-eudesoml and nootkatone showed good binding affinity α-glucosidase and α-amylase and all tested compounds showed the higher binding affinity towards the enzyme tyrosinase.
Yazarlar (15)
1
Rameen Sajid
2
Zaheer Abbas
3
Mamona Nazir
4
Muhammad Saleem
5
Naheed Riaz
6
Muhammad Imran Tousif
7
Saba Tauseef
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
9
Abdullahi Ibrahim Uba
10
Abdullah Ijaz Hussain
11
Muhammad Shaiq Ali
12
Abeer Hashem
13
Khalid F. Almutairi
14
Graciela Dolores Avila-Quezada
15
Elsayed Fathi Abd-Allah
Anahtar Kelimeler
Antioxidant
Citrus paradisi cultivar foster
Enzyme inhibition
Essential oil
GC-MS analysis
In silico studies
Kurumlar
College of Sciences
Riyadh Saudi Arabia
İstanbul Arel Üniversitesi
Istanbul Turkey
King Saud University
Riyadh Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
The Government Sadiq College Women University Bahawalpur
Bahawalpur Pakistan
The Islamia University of Bahawalpur
Bahawalpur Pakistan
The University of Faisalabad
Faisalabad Pakistan
Universidad Autónoma de Chihuahua
Chihuahua Mexico
University of Education
Lahore Pakistan
University of Karachi
Karachi Pakistan