Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Harnessing the chemical composition and anti-oxidant, anti-enzymatic, and anti-cancer activities of two Corydalis species (C. erdelii and C. solida) by using in vitro and in silico analysis
Food Bioscience · Ekim 2024
YÖKSİS Kayıtları
Harnessing the chemical composition and anti-oxidant, anti-enzymatic, and anti-cancer activities of two Corydalis species (C. erdelii and C. solida) by using in vitro and in silico analysis
Food Bioscience · 2024 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties
2018 ISSN: 2212-4292 SCI-Expanded
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Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties
2018 ISSN: 2212-4292 SCI
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Pigmented whole maize grains for functional value added and low glycemic index snack production
2021 ISSN: 2212-4292 SCI-Expanded Q1
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Pigmented Whole Maize Grains for Functional Value Added and Low Glycemic Index Snack Production
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Storage stability, heat stability, controlled release and antifungal activity of liposomes as alternative fungal preservation agents
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2024 ISSN: 2212-4292 SCI-Expanded Q1
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Harnessing the chemical composition and anti-oxidant, anti-enzymatic, and anti-cancer activities of two Corydalis species (C. erdelii and C. solida) by using in vitro and in silico analysis
2024 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. EVREN YILDIZTUGAY →
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Effects of ultrasound-assisted marination on spent hen meats: Microstructure, textural and technological properties
2024 ISSN: 2212-4292 SCI-Expanded Q1
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Exploring the chemical constituents and biological activities of leaf and twig extracts of two Amygdalus species from Turkeys flora: Cell-free, in vitro and molecular docking approaches
2025 ISSN: 2212-4292 SCI-Expanded Q1
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2024 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
Dergi
Food Bioscience
ISSN22124292
Yayın TarihiEkim 2024
Cilt / Sayfa61
Scopus ID2-s2.0-85198983780
Özet
In search of a powerful source of bioactive molecules that can be imperative in maintaining health, this paper studies two Corydalis species from the territory of Turkey. Namely, C. erdelii Zucc. and C. solida (L.) Clairv. were extracted with ethanol using homogenized-assisted extraction, and infusions of these two plant species were obtained using water. The obtained extracts and infusions were characterized in terms of chemical composition, namely in terms of the content of total phenols and flavonoids, as well as individual polyphenolic components using the LC-method of analysis. Along with the examination of the chemical composition, their biological activity was also determined using a series of tests that defined their antioxidant, antidiabetic, neuroprotective and cytotoxic activity. The obtained results showed that infusion of C. solida was richer with biomolecules capable to neutralize DPPH, ABTS radicals but also with better reduction power. Ethanolic extracts also showed a higher degree of inhibition of the observed enzymes. Treatment of A549 lung cancer cells with Corydalis extracts, especially ethanol extracts, triggered up-regulation of apoptotic and ER stress pathway genes, potentially attributed to compounds like quercetin and verbascoside. C. erdelii demonstrated superior apoptotic activity compared to C. solida, possibly due to unique compounds. In BEAS-2B cells, Corydalis extracts induced apoptosis while suppressing ER stress, suggesting a mechanism primarily driven by apoptosis. The molecular docking study identified eight compounds from Corydalis extracts with strong inhibitory activity against enzymes. Compounds like kaempferol 3-O-rhamnoside, rhamnocitrin 3-rhamnoside, and verbascoside showed stable interactions with proteins, suggesting their potential for further drug development.
Yazarlar (11)
1
Tugce Duran
ORCID: 0000-0002-7353-4527
2
Gregorio Peron
ORCID: 0000-0002-6007-6184
3
Mirella Zancato
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Mehmet Veysi Cetiz
ORCID: 0000-0002-2635-6553
6
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
7
Shakel Ahmed
8
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
9
Stefano Dall'Acqua
10
Aleksandra Cvetanović Kljakić
11
Carlos L. Cespedes-Acuña
ORCID: 0000-0002-3715-3268
Anahtar Kelimeler
Anti-cancer
Antioxidant
Corydalis
Functional application
Molecular docking
Kurumlar
CSIC-UAM - Instituto de Investigacion en Ciencias de la Alimentacion (CIAL)
Madrid Spain
Faculté des Sciences Rabat
Rabat Morocco
Julius-Maximilians-Universität Würzburg
Wurzburg Germany
Karatay Üniversitesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Universidad del Bio Bio
Concepcion Chile
Università degli Studi di Brescia
Brescia Italy
Università degli Studi di Padova
Padua Italy
University of Novi Sad
Novi Sad Serbia
Scimago Dergi (ISSN Eşleşmesi)
Food Bioscience
Q1
SJR Skoru1,119
H-Index94
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Biochemistry (Q1)
Food Science (Q1)
Metrikler
25
Atıf
11
Yazar
5
Anahtar Kelime