Scopus
Coordination and bioinorganic chemistry at the heart of metallodrugs: Knowledge gaps and future directions
Inorganica Chimica Acta · Kasım 2024
Makale Bilgileri
DergiInorganica Chimica Acta
Yayın TarihiKasım 2024
Cilt / Sayfa572
Scopus ID2-s2.0-85200761301
Özet
Transition metals are an integral part of medicinal inorganic chemistry. These metals exist in distinct oxidation states and are found to interact with several negatively charged molecules. This nature of transition has been utilized in the advancement of potential drugs for the ailments of malignant diseases including cancer. These heavy metal complexes are scaffolds in the designing of numerous advanced therapeutics for mitigating inflammation, rheumatoid arthritis, cancer, cardiovascular disease, and diabetes mellitus. Metal complexes are also employed as prominent chelating agents augmenting the bioactivity and efficiency of existing drugs. The behavior of metal ions in biological fluid and further toxicity is interpreted through coordination chemistry. The review addresses the fundamentals of coordination and inorganic chemistry comprehensively. This review provides an extensive understanding of how coordination and inorganic chemistry govern the activity of metallodrugs and chelating agents. It also delves into the chemistry behind the available metallodrugs and chelating agents concerning their various pharmaceutical applications.
Yazarlar (4)
1
Nabeelah Bibi Sadeer
ORCID: 0000-0002-0602-0059
2
Ressin Varghese
3
Siva Ramamoorthy
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
Cancer
Chelate effect
Crystal field theory
DNA interaction
Geometry
Transition metals
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of Mauritius
Reduit Mauritius
Vellore Institute of Technology
Vellore India