Scopus
🔓 Açık Erişim
Secondary metabolic profiling, antioxidant potential, enzyme inhibitory activities and in silico and ADME studies: a multifunctional approach to reveal medicinal and industrial potential of Tanacetum falconeri
BMC Complementary Medicine and Therapies · Aralık 2024
Makale Bilgileri
DergiBMC Complementary Medicine and Therapies
Yayın TarihiAralık 2024
Cilt / Sayfa24
Scopus ID2-s2.0-85190835380
Erişim🔓 Açık Erişim
Özet
Tanacetum falconeri is a significant flowering plant that possesses cytotoxic, insecticidal, antibacterial, and phytotoxic properties. Its chemodiversity and bioactivities, however, have not been thoroughly investigated. In this work, several extracts from various parts of T. falconeri were assessed for their chemical profile, antioxidant activity, and potential for enzyme inhibition. The total phenolic contents of T. falconeri varied from 40.28 ± 0.47 mg GAE/g to 11.92 ± 0.22 mg GAE/g in various extracts, while flavonoid contents were found highest in TFFM (36.79 ± 0.36 mg QE/g extract) and lowest (11.08 ± 0.22 mg QE/g extract) in TFSC (chloroform extract of stem) in similar pattern as found in total phenolic contents. Highest DPPH inhibition was observed for TFFC (49.58 ± 0.11 mg TE/g extract) and TFSM (46.33 ± 0.10 mg TE/g extract), whereas, TFSM was also potentially active against (98.95 ± 0.57 mg TE/g) ABTS radical. In addition, TFSM was also most active in metal reducing assays: CUPRAC (151.76 ± 1.59 mg TE/g extract) and FRAP (101.30 ± 0.32 mg TE/g extract). In phosphomolybdenum assay, the highest activity was found for TFFE (1.71 ± 0.03 mg TE/g extract), TFSM (1.64 ± 0.035 mg TE/g extract), TFSH (1.60 ± 0.033 mg TE/g extract) and TFFH (1.58 ± 0.08 mg TE/g extract), while highest metal chelating activity was recorded for TFSH (25.93 ± 0.79 mg EDTAE/g extract), TFSE (22.90 ± 1.12 mg EDTAE/g extract) and TFSC (19.31 ± 0.50 mg EDTAE/g extract). In biological screening, all extracts had stronger inhibitory capacity against AChE while in case of BChE the chloroform extract of flower (TFFC) and stem (TFSC) showed the highest activities with inhibitory values of 2.57 ± 0.24 and 2.10 ± 0.18 respectively. Similarly, TFFC and TFSC had stronger inhibitory capacity (1.09 ± 0.015 and 1.08 ± 0.002 mmol ACAE/g extract) against α-Amylase and (0.50 ± 0.02 and 0.55 ± 0.02 mmol ACAE/g extract) α-Glucosidase. UHPLC-MS study of methanolic extract revealed the presence of 133 components including sterols, triterpenes, flavonoids, alkaloids, and coumarins. The total phenolic contents were substantially linked with all antioxidant assays in multivariate analysis. These findings were validated by docking investigations, which revealed that the selected compounds exhibited high binding free energy with the enzymes tested. Finally, it was found that T. falconeri is a viable industrial crop with potential use in the production of functional goods and nutraceuticals.
Yazarlar (14)
1
Muhammad Imran Tousif
2
Zaheer Abbas
3
Mamona Nazir
4
Muhammad Saleem
5
Saba Tauseef
6
Areeba Hassan
7
Sajid Ali
8
Maqsood Ahmed
9
Jallat Khan
10
Gokhan Zengin
ORCID: 0000-0001-6548-7823
11
Abeer Hashem
12
Khalid F. Almutairi
13
Graciela Dolores Avila-Quezada
14
Elsayed Fathi Abd-Allah
Anahtar Kelimeler
Enzyme inhibition activities
In silico studies
Tanacetum falconeri
Total bioactive contents; antioxidant activities
Kurumlar
College of Sciences
Riyadh Saudi Arabia
Khwaja Fareed University of Engineering & Information Technology
Rahim Yar Khan Pakistan
King Saud University
Riyadh Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
The Government Sadiq College Women University Bahawalpur
Bahawalpur Pakistan
The Islamia University of Bahawalpur
Bahawalpur Pakistan
Universidad Autónoma de Chihuahua
Chihuahua Mexico
University of Education
Lahore Pakistan
University of Karachi
Karachi Pakistan
Metrikler
1
Atıf
14
Yazar
4
Anahtar Kelime