Scopus
Prognostic factors in clinical stage T4N2 locally advanced non-small cell lung cancer
Journal of B.U.ON. · Mart 2015
Makale Bilgileri
DergiJournal of B.U.ON.
Yayın TarihiMart 2015
Cilt / Sayfa20 · 573-579
Scopus ID2-s2.0-84930746599
Özet
Purpose: Relatively few studies have focused on T4N2 (stage HIB) locally advanced non-small cell lung cancer (NSCLC). In this study, we tried to identify prognostic factors for patients with clinical stage T4N2 NSCLC. Methods: We retrospectively identified 223 patients, of which 168 met the inclusion criteria. Patients treated with curative intent using concurrent chemoradiotherapy (CRT) with or without adjuvant chemotherapy, or concurrent CRT after induction chemotherapy, were included in this study. Relevant patient, treatment, and disease factors were evaluated for their prognostic significance in both univariate and multivariate analyses using the Cox proportional hazards model. Results: The median progression-free survival (PFS) was 13 months (95% confidence interval [CI], 10.6-15.4). The median overall survival (OS) was 20 months (95% CI, 16.8-23.1), and 71, 40.3 and 28.2% of the patients survived for 1,2 and 3 years after diagnosis, respectively. Multivariate analysis showed Eastern Cooperative Oncology Group (ECOG) performance status (PS) was independent predictor of PFS (hazard ratio [HR], 0.24; 95% CI, 0.13-0.43; p=0.001), and OS [HR, 0.48; 95% CI, 0.26-0.87; p=0.015). Absence of multifocal T4 tumors was also associated with a significantly longer OS (HR, 046; 95% CI, 0.31-0.7; p=0.001). There was no statistically significant difference in OS and PFS between treatment modalities. Conclusion: PFS and OS were significantly shorter in patients with poor ECOG PS. OS was also significantly shorter in patients with multifocal T4 tumors. There were no differences between the two therapeutic approaches with respect to outcome.
Yazarlar (19)
1
Deniz Arslan
2
Deniz Tural
3
Timur Koca
4
Didem Tastekin
5
Arda Kaymak Cerkesli
6
Hamit Basaran
7
Seyda Gunduz
8
Ali Murat Tatli
9
Sema Sezgin Goksu
10
Mükremin Uysal
11
Aysegul Kargi
12
Bulent Kargi
13
Lokman Koral
14
Cumhur Ibrahim Bassorgun
15
Dilek Unal
16
Hasan Mutlu
17
H. S. Coskun
ORCID: 0000-0003-2969-7561
18
Mustafa Ozdogan
19
Hakan Bozcuk
Anahtar Kelimeler
Clinical stage T4N2
Locally advanced non-small cell lung cancer
Patient outcome
Prognostic factors
Survival
Treatment modality
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Akdeniz Üniversitesi
Antalya Turkey
Antalya Education and Research Hospital
Antalya Turkey
Canakale Research and Education Hospital
Canakale Turkey
Erzurum Education and Research Hospital
Erzurum Turkey
İstanbul Tıp Fakültesi
Istanbul Turkey
Kayseri Education and Research Hospital
Kayseri Turkey
Medical Park Hospital
Bursa Turkey
Medstar Antalya Hospital
Antalya Turkey
Van Education and Research Hospital
Van Turkey
Metrikler
5
Atıf
19
Yazar
6
Anahtar Kelime