Scopus
YÖKSİS Eşleşti
The role of fatty acids in patients with Behçet's disease and their association with thrombosis
Lipids · Ocak 2024
YÖKSİS Kayıtları
The Role of Fatty Acids in Patients with Behçet’s Disease and Their Association with Thrombosis
Lipids · 2024 SCI-Expanded
PROFESÖR SEMA YILMAZ →
The role of fatty acids in patients with Behçets disease and their association with thrombosis
Lipids · 2024 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
The role of fatty acids in patients with Behçets disease and their association with thrombosis
Lipids · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Makale Bilgileri
DergiLipids
Yayın TarihiOcak 2024
Scopus ID2-s2.0-85192995121
Özet
Behçet's disease (BD) is a systemic disease with unknown etiopathogenesis and varying disease presentations. Fatty acids (FA) are essential biological compounds that are involved in complex metabolic pathways. They may contribute to inflammation and endothelial dysfunction by participating in many signaling pathways. Increased FAs levels are associated with an increased risk for various diseases. This study aimed to determine the relationship between FA, BD, and thrombotic complications. A total of 97 patients were recruited from the rheumatology department of a single center as a case–control study. The participants were divided into three groups: 36 patients with BD with thrombosis (Group 1), 24 patients with BD without thrombosis (Group 2), and 37 age- and sex-matched controls (Group 3). The analysis of 37 different FA with carbon numbers in the range of (4:0) and (24:1) in the samples were analyzed and compared between groups. Myristic acid (MA), methyl eicosatrienoate, and stearic acid (STA) levels were found to be significantly higher in BD with thrombosis than in BD without thrombosis, and palmitic acid (PA) levels were significantly higher in BD with thrombosis than in healthy individuals. MA was found to be a significant marker for differentiating between thrombotic BD. PA and STA are important markers for detecting thrombotic BD. In BD, lipotoxicity created by FA, such as PA, STA, and MA, plays a role as an inducer of inflammation and thrombosis through various mechanisms.
Yazarlar (7)
1
Dilek Tezcan
ORCID: 0000-0002-8295-9770
2
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
3
M. K. Korez
ORCID: 0000-0001-9524-6115
4
Muhammet Limon
ORCID: 0000-0002-5693-7885
5
Semral Gülcemal
ORCID: 0000-0002-6085-9939
6
Sema Yılmaz
ORCID: 0000-0003-4277-3880
7
Abdullah Sivrikaya
Anahtar Kelimeler
Behçet's disease
fatty acids
inflammation
thrombosis
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey