Scopus
YÖKSİS Eşleşti
Results of radiotherapy in squamous cell laryngeal cancer: A tomotherapy center experience
Indian Journal of Cancer · Temmuz 2022
YÖKSİS Kayıtları
Results of radiotherapy in squamous cell laryngealcancer: A tomotherapy center experience
INDIAN JOURNAL OF CANCER · 2022 SCI-Expanded
DOÇENT HAMİT BAŞARAN →
Makale Bilgileri
DergiIndian Journal of Cancer
Yayın TarihiTemmuz 2022
Cilt / Sayfa59 · 330-336
Scopus ID2-s2.0-85142403516
Özet
Background: Laryngeal cancer is a common type of head and neck cancer (HNC). Radiotherapy (RT) is a mainstay for curative treatment. Intensity-modulated RT (IMRT) is a standard technique today, as it provides of higher survival and local control and lower normal tissue toxicity. One of IMRT devices is helical tomotherapy (HT). The HT treatment results of HNC patients have been reported in few studies. We aimed to investigate the results of squamous cell laryngeal carcinoma patients treated with helical tomotherapy. Methods: Forty-five laryngeal cancer patients were selected according to the inclusion criteria. Radiotherapy (RT) plans were set in the Hi-Art HT planning system. Image-gated RT (IGRT) technique was used. Appropriate patients received simultaneous cisplatin. Treatment response rates were evaluated at the post-RT third and sixth months. Survival times were calculated with the Kaplan–Meier method. The factors affecting the treatment results were evaluated using Log-rank and Cox regression tests. A P value of less than 0.05 was accepted as statistically significant. Results: The median age was 65 (28–84) years. The median symptom duration was 6 (1–60) months. The RT dose for the early and the locally advanced disease was median 63 Gy (60.75–66) and 66 Gy (60–70), respectively. The RT interruption was median two (0-20) days. The patients were followed up to 25 (1–45) months. Grade 2 xerostomia and dysphagia rates were 55% and 7%, respectively. The 3-year estimates of overall survival (OS), disease-free survival (DFS), metastasis-free survival (DMFS), and locoregional recurrence-free survival (RRFS) were 71.7%, 60.4%, 84.9%, and 68.5%, respectively. In univariate analysis, the presence of N2 disease was a negative prognostic for DFS (P = 0.05) and DMFS (P = 0.003). RT interruption >2 days was a negative prognostic for OS (P = 0.005), DFS (P = 0.02), and RRFS (P = 0.023). In the multivariate analysis, symptom duration >6 months was found to be the only significant factor for DFS (P < 0.05). Conclusion: Intensity-modulated radiation with HT achieved comparable clinical outcomes with acceptable toxicity in laryngeal carcinoma.
Yazarlar (4)
1
Meltem Kirli Bolukbas
ORCID: 0000-0002-4008-4187
2
Menekse Turna
ORCID: 0000-0001-7464-7307
3
Sibel Karaca
ORCID: 0000-0003-0957-3932
4
Hamit Basaran
Anahtar Kelimeler
Helical tomotherapy
laryngeal cancer
radiotherapy
retrospective analysis
treatment results
Kurumlar
Health Sciences University Erzurum Regional Education and Research Hospital
Yakutiye Turkey
Metrikler
1
Atıf
4
Yazar
5
Anahtar Kelime