Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Novel indole-based analogs of melatonin: Synthesis and in vitro antioxidant activity studies
Molecules · Nisan 2010
YÖKSİS Kayıtları
Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies
MOLECULES · 2010 SCI
DOÇENT HANİF ŞİRİNZADE →
Makale Bilgileri
DergiMolecules
Yayın TarihiNisan 2010
Cilt / Sayfa15 · 2187-2202
Scopus ID2-s2.0-77951829441
Erişim🔓 Açık Erişim
Özet
The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H2O2-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH-induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin. Copyright © 2010 by the authors.
Yazarlar (5)
1
Hanif Şirinzade
2
Burcu Eren
3
Hande Gurer-Orhan
4
Sibel Süzen
5
Seckin Ozden
Anahtar Kelimeler
Antioxidant activity
Hydrazide
Hydrazone
Indole
Melatonin
Synthesis
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Ege Üniversitesi
Izmir Turkey
Metrikler
74
Atıf
5
Yazar
6
Anahtar Kelime