Scopus
YÖKSİS Eşleşti
Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: Evaluation of interactions using FT-IR and NMR spectroscopies
International Journal of Pharmaceutics · Şubat 2011
YÖKSİS Kayıtları
Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: Evaluation of interactions using FT-IR and NMR spectroscopies
INTERNATIONAL JOURNAL OF PHARMACEUTICS · 2011 SCI
DOÇENT HANİF ŞİRİNZADE →
Makale Bilgileri
DergiInternational Journal of Pharmaceutics
Yayın TarihiŞubat 2011
Cilt / Sayfa404 · 102-109
Scopus ID2-s2.0-78650677015
Özet
The purpose of this study was to form indomethacin (IND)-loaded poly(methyl methacrylate) (PMMA) microspheres having an extended drug release profile over a period of 24 h. Microspheres were prepared by solvent evaporation method using sucrose stearate as a droplet stabilizer. When PMMA was used alone for the preparation of microspheres, only 44% of IND could be released at the end of 8 h. Triacetin was added to PMMA, as a minor phase, and the obtained microspheres showed a high yield process with recovery of 89.82% and incorporation efficiency of 102.3%. A desired release profile lasting 24 h was achieved. Differential scanning calorimetry (DSC) analysis showed that IND was found to be in an amorphous state in the microspheres. Fourier transform infrared (FT-IR) and nuclear magnetic resonance (1H NMR) spectra suggested that there might be a hydrogen bond present between the IND hydroxyl group and PMMA. No interaction between triacetin and IND or PMMA as the formation of secondary bonds was observed. The release enhancement of IND from microspheres was attributed to the physical plasticization effect of triacetin on PMMA and, to some extent, the amorphous state of the drug. © 2010 Elsevier B.V. All rights reserved.
Yazarlar (4)
1
Nilufer Yuksel
2
Meltem Baykara
3
Hanif Şirinzade
4
Sibel Süzen
Anahtar Kelimeler
Amorphous
Extended release
Indomethacin
Microspheres
Poly(methyl methacrylate)
Triacetin
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Metrikler
35
Atıf
4
Yazar
6
Anahtar Kelime