Scopus
YÖKSİS Eşleşti
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: Bioisosteric melatonin analogues
Journal of Enzyme Inhibition and Medicinal Chemistry · Ocak 2016
YÖKSİS Kayıtları
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY · 2016 SCI
DOÇENT HANİF ŞİRİNZADE →
Makale Bilgileri
DergiJournal of Enzyme Inhibition and Medicinal Chemistry
Yayın TarihiOcak 2016
Cilt / Sayfa31 · 121-125
Scopus ID2-s2.0-84953337370
Özet
Overproduction of reactive oxygen species results in oxidative stress that can cause fatal damage to vital cell structures. It is known that the use of antioxidants could be beneficial in the prevention or delay of numerous diseases associated with oxidative stress. Melatonin (MLT) is known as a powerful free-radical scavenger and antioxidant. It was found that indole ring of MLT can be employed by bioisosteric replacement by other aromatic rings. Quinoline derivatives constitute an important class of compounds for new drug development. Owing to quinoline and hydrazones appealing physiological properties and are mostly found in numerous biologically active compounds a series of quinoline-2-carbaldehyde hydrazone derivatives were synthesized as bioisosteric analogues of MLT, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox-sensitive fluorescent probe. Cytotoxicity potential of all compounds was investigated both by lactate dehydrogenase leakage assay and by MTT assay.
Yazarlar (5)
1
M. Orhan Puskullu
2
Hanif Şirinzade
3
Merve Nenni
4
Hande Gurer-Orhan
5
Sibel Süzen
Anahtar Kelimeler
Antioxidant
hydrazone
lactate dehydrogenase leakage
melatonin
MTT
quinoline
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Ege Üniversitesi
Izmir Turkey
Erciyes Üniversitesi
Kayseri Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Metrikler
53
Atıf
5
Yazar
6
Anahtar Kelime