Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
Journal of Enzyme Inhibition and Medicinal Chemistry · Kasım 2016
YÖKSİS Kayıtları
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY · 2016 SCI
DOÇENT HANİF ŞİRİNZADE →
Makale Bilgileri
DergiJournal of Enzyme Inhibition and Medicinal Chemistry
Yayın TarihiKasım 2016
Cilt / Sayfa31 · 1312-1321
Scopus ID2-s2.0-84953727931
Erişim🔓 Açık Erişim
Özet
Melatonin (MLT) is a well-known free-radical scavenger, involving in the prevention of cellular damage that can lead to cancer, ageing and a variety of neurodegenerative diseases. Research on MLT-related compounds has been required to optimise the maximum pharmaceutical activity with the lowest side effects. In our ongoing research, we have synthesized new indole-based MLT analogues as potential antioxidant agents by modifying the MLT molecule. In this study, we build on previous findings, through the synthesis, characterization and in vitro antioxidant profiling of a series of new indole-based MLT analogues which possess triazole, thiadiazole and carbothioamides on the third position on the indole ring. In vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe and their radical scavenging activity was assessed via the DPPH assay. In addition, in vitro cytotoxic effects of newly synthesized compounds were investigated in CHO-K1 cells using the MTT assay.
Yazarlar (5)
1
Hanif Şirinzade
2
Elif Ince Erguc
3
Andrew D. Westwell
4
Hande Gurer-Orhan
5
Sibel Süzen
Anahtar Kelimeler
Antioxidant
antioxidant activity
cytotoxicity
indole
melatonin
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Cardiff University
Cardiff United Kingdom
Ege Üniversitesi
Izmir Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Metrikler
25
Atıf
5
Yazar
5
Anahtar Kelime