Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Antimicrobial activities of new indole derivatives containing 1,2,4-triazole, 1,3,4-thiadiazole and carbothioamide
Turkish Journal of Pharmaceutical Sciences · Aralık 2018
YÖKSİS Kayıtları
Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide
The Turkish Journal of Pharmaceutical Sciences · 2018 EI: Engineering Index
DOÇENT HANİF ŞİRİNZADE →
Makale Bilgileri
DergiTurkish Journal of Pharmaceutical Sciences
Yayın TarihiAralık 2018
Cilt / Sayfa15 · 291-297
Scopus ID2-s2.0-85062059516
Erişim🔓 Açık Erişim
Özet
Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. Materials and Methods: The efficacy of new compounds was evaluated using 2-fold serial dilutions against Staphylococcus aureus, MRSA, Escherichia coli, Bacillus subtilis, Candida albicans, and Candida krusei. Results: The MIC was determined for test compounds and for the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin. Conclusion: The compounds possessed a broad spectrum of activity having MIC values of 3.125-50 µg/mL against the tested microorganisms. This study provides valuable evidence that the indole-triazole derivative compound 3d holds significant promise as a novel antibacterial and antifungal lead compound.
Yazarlar (4)
1
Hanif Şirinzade
2
Sibel Süzen
3
Nurten Altanlar
4
Andrew D. Westwell
Anahtar Kelimeler
1,2,4-triazole
1,3,4-thiadiazole
C. krusei
Indole
MRSA
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Cardiff University
Cardiff United Kingdom
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Metrikler
30
Atıf
4
Yazar
5
Anahtar Kelime