Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Antimicrobial activities of new indole derivatives containing 1,2,4-triazole, 1,3,4-thiadiazole and carbothioamide
Turkish Journal of Pharmaceutical Sciences · Aralık 2018
YÖKSİS Kayıtları
Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide
The Turkish Journal of Pharmaceutical Sciences · 2018 EI: Engineering Index
Doç. Dr. HANİF ŞİRİNZADE →
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2019 ISSN: 1304-530X Scopus
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Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide
2018 ISSN: 1304-530X EI: Engineering Index
Doç. Dr. HANİF ŞİRİNZADE →
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The Potential Drug Interactions Between Multiple Sclerosis and COVID-19 Therapies
2021 ISSN: 1304-530X ESCI, PMC, PUBMED, ULAKBİM TR-DİZİN, SCOPUS, ...
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In Vitro Antioxidant and Enzyme Inhibition Activity of Tanacetum argyrophyllum (K. Koch) Tzvelev var. argyrophyllum Extract
2022 ISSN: 1304-530X Web of Science - Emerging Sources Citation Index (ESCI)
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Makale Bilgileri
ISSN1304530X
Yayın TarihiAralık 2018
Cilt / Sayfa15 · 291-297
Scopus ID2-s2.0-85062059516
Erişim🔓 Açık Erişim
Özet
Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. Materials and Methods: The efficacy of new compounds was evaluated using 2-fold serial dilutions against Staphylococcus aureus, MRSA, Escherichia coli, Bacillus subtilis, Candida albicans, and Candida krusei. Results: The MIC was determined for test compounds and for the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin. Conclusion: The compounds possessed a broad spectrum of activity having MIC values of 3.125-50 µg/mL against the tested microorganisms. This study provides valuable evidence that the indole-triazole derivative compound 3d holds significant promise as a novel antibacterial and antifungal lead compound.
Yazarlar (4)
1
Hanif Şirinzade
2
Sibel Süzen
3
Nurten Altanlar
4
Andrew D. Westwell
Anahtar Kelimeler
1,2,4-triazole
1,3,4-thiadiazole
C. krusei
Indole
MRSA
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Cardiff University
Cardiff United Kingdom
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Pharmaceutical Sciences
Q2
OA
SJR Skoru0,440
H-Index26
YayıncıTurkish Pharmacists Association
ÜlkeTurkey
Pharmaceutical Science (Q2)
Molecular Medicine (Q3)
Metrikler
42
Atıf
4
Yazar
5
Anahtar Kelime