Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Bioisosteric modification on melatonin: Synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies
Brazilian Journal of Pharmaceutical Sciences · Ocak 2020
YÖKSİS Kayıtları
Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES · 2020 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies
Brazilian Journal of Pharmaceutical Sciences · 2020 SCI-Expanded
Doç. Dr. HANİF ŞİRİNZADE →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Cytotoxic evaluation and LC-MS/MS analysis of aerial parts of Eryngium kotschyi Boiss. grown in Turkey
2022 ISSN: 1984-8250 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
Makale Bilgileri
ISSN19848250
Yayın TarihiOcak 2020
Cilt / Sayfa56 · 1-11
Scopus ID2-s2.0-85088937078
Erişim🔓 Açık Erişim
Özet
Melatonin (MLT) is a strong free radical scavenger that protects the body from the deleterious effects of excess oxidants. Synthesis of MLT analogue compounds with antioxidant potency has recently attracted the interest of researchers. In general, the strategy consists of modifying the groups in the different sites of the indole ring or replacing the indole ring with an analogue. As part of our ongoing research, the antioxidant capacity and cytotoxicity of newly synthesized MLT analogue naphthalene derivatives were evaluated. The radical scavenging activity was tested by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Most of the synthesized compounds showed significant antioxidant activity in comparison to MLT. The structure-activity relationship was identified. The in vitro cytotoxic effects of the synthesized compounds were also investigated in CHO-K1 cells using the MTT assay.
Yazarlar (7)
1
Hanif Şirinzade
2
Mohammed Ghalia
3
Alev Tascioglu Aliyev
4
Ferial Intissar Adjali
5
Gulsen Gunesacar
6
Hande Gurer-Orhan
7
Sibel Süzen
Anahtar Kelimeler
Antioxidant
Cytotoxic
DPPH
Melatonin
MTT
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Ege Üniversitesi
Izmir Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Université Constantine 1
Constantine Algeria
Scimago Dergi (ISSN Eşleşmesi)
Brazilian Journal of Pharmaceutical Sciences
Q3
OA
SJR Skoru0,242
H-Index53
YayıncıFaculdade de Ciencias Farmaceuticas (Biblioteca)
ÜlkeBrazil
Pharmacology, Toxicology and Pharmaceutics (miscellaneous) (Q3)
Metrikler
10
Atıf
7
Yazar
5
Anahtar Kelime