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New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Bioorganic Chemistry · Kasım 2020

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YÖKSİS Kayıtları
New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential
BIOORGANIC CHEMISTRY · 2020 SCI-Expanded
Doç. Dr. HANİF ŞİRİNZADE →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 19 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix 4 arene bearing iminodicarboxylic phosphonic acid complexes modified iron oxide nanoparticles
2016 ISSN: 00452068 SCI-Expanded
Prof. Dr. ELİF ÖZYILMAZ →
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix 4 arene bearing iminodicarboxylic phosphonic acid complexes modified iron oxide nanoparticles
2016 ISSN: 00452068 SCI
Prof. Dr. MUSTAFA YILMAZ →
Synthesis and evaluation of the antitumor activity of Calix [4] arene l-proline derivatives
2020 ISSN: 0045-2068 SCI
Prof. Dr. MUSTAFA YILMAZ →
Investigation of Inhibitory Properties of Some Hydrazone Compounds on hCA I, hCA II and AChE Enzymes
2019 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Antibacterial activities and DNA-cleavage properties of novel fluorescent imidazo-phenanthroline derivatives
2020 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. EMİNE ARSLAN →
Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors
2020 ISSN: 0045-2068 SCI-Expanded
Dr. Öğr. Üyesi MERVE GÖKŞİN KARAASLAN TUNÇ →
Synthesis and evaluation of the antitumor activity of Calix[4]arene l-proline derivatives
2020 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. MUSTAFA YILMAZ →
Synthesis and evaluation of the antitumor activity of Calix[4]arene l-proline derivatives
2020 ISSN: 0045-2068 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential
2020 ISSN: 0045-2068 SCI-Expanded
Doç. Dr. HANİF ŞİRİNZADE →
Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo IIα
2021 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi FATMA ZİLİFDAR FOTO →
Ortho-hydroxy bioactive schiff base compounds: Design, comprehensive characterization, photophysical properties and elucidation of antimicrobial and mutagenic potentials
2022 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi MUSTAFA KUL →
Biological activity and ADME/Tox prediction of some 2-substituted benzoxazole derivatives
2022 ISSN: 0045-2068 SCI Q1
Dr. Öğr. Üyesi FATMA ZİLİFDAR FOTO →
Ortho-hydroxy bioactive schiff base compounds: Design, comprehensive characterization, photophysical properties and elucidation of antimicrobial and mutagenic potentials
2022 ISSN: 0045-2068 SCI-Expanded
Doç. Dr. ASLIHAN YILMAZ OBALI →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. AHMET UYSAL →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Preparation of water-soluble imidazole-functionalized pillar[5]arenes: The activities of antibacterial and antioxidant, catalytic reduction of 4-nitrophenol
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. MUSTAFA ÖZMEN →
Investigation of 2-substituted-5-methylsulfonylbenzoxazole derivatives as potential cholinesterase inhibitors: Synthesis, in vitro, and computational studies
2025 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Creative approaches for antibacterial, antioxidant and anticancer using honeycomb-type agents derived from a natural polymer
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. AHMED NURİ KURŞUNLU →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →

Makale Bilgileri

Dergi Bioorganic Chemistry
ISSN00452068
Yayın TarihiKasım 2020
Cilt / Sayfa104
DOI10.1016/j.bioorg.2020.104219
Scopus ID2-s2.0-85090353710
Özet Over the last decade, there has been substantial interest in the use of melatonin (MLT) and MLT-like compounds in the treatment of several diseases. MLT can scavenge different reactive oxygen species and can also stimulate the synthesis of antioxidant enzymes. Our ongoing study relies on changing the groups in the different modifiable sites of the indole ring to increase the antioxidant activity. In this study a new approach for substitution of indole ring as indole based MLT analogue was proposed. We report the synthesis and characterization of a series of new indole-7-aldehyde hydrazide/hydrazone derivatives as indole-based MLT analogues. Anticancer potential of the compounds were evaluated both by their antioxidant and CYP1 inhibitory activities. In vitro antioxidant capacity of the compounds was investigated both in a cell-based (DCFH assay) and a cell-free (DPPH assay) assay. Potential inhibitory effects of the compounds on CYP1 catalytic activity were investigated via EROD assay. Cytotoxic activity of the compounds was further evaluated by the MTT assay in CHO-K1 cells. MLT analogues having an o-halogenated aromatic moiety exhibited effective antioxidant properties without having any cytotoxic effect. In conclusion, MLT derivatives represent promising scaffolds for discovery of effective antioxidant agents.

Yazarlar (6)

1
Hanif Şirinzade
2
Eddy Neuhaus
3
Elif Ince Erguc
4
Alev Tascioglu Aliyev
5
Hande Gurer-Orhan
6
Sibel Süzen

Anahtar Kelimeler

Antioxidant activity CYP1 inhibition Cytotoxicity Indole Melatonin Synthesis

Kurumlar

Ankara Üniversitesi
Ankara Turkey
Ege Üniversitesi
Izmir Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Scimago Dergi (ISSN Eşleşmesi)
Bioorganic Chemistry
Q1
SJR Skoru0,786
H-Index95
YayıncıAcademic Press Inc.
ÜlkeUnited States
Organic Chemistry (Q1)
Biochemistry (Q2)
Drug Discovery (Q2)
Molecular Biology (Q3)
Dergi sayfasına git

Metrikler

26
Atıf
6
Yazar
6
Anahtar Kelime

Sistemimizdeki Yazarlar

HŞ
HANİF ŞİRİNZADE
Doç. Dr.

Hızlı Erişim

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