Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Synthesis, characterization and biological activity evaluation of novel naphthalenylmethylen hydrazine derivatives as carbonic anhydrase inhibitors
Journal of Molecular Structure · Kasım 2020
YÖKSİS Kayıtları
Synthesis, characterization and biological activity evaluation of novel naphthalenylmethylen hydrazine derivatives as carbonic anhydrase inhibitors
Journal of Molecular Structure · 2020 SCI
Doç. Dr. HANİF ŞİRİNZADE →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
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New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
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Makale Bilgileri
ISSN00222860
Yayın TarihiKasım 2020
Cilt / Sayfa1220
Scopus ID2-s2.0-85086509133
Özet
In the current study some derivatives of naphthalenylmethylen hydrazine were synthesized and possible in vitro hCA I and II enzymes inhibition effects were investigated. The designed compounds were synthesized by condensation of phenylhydrazine with 1-naphthaldehyde or 6-methoxy-2-naphthaldehyde and eight compounds (1a-h) were obtained. The novel Schiff bases derivatives (compounds 1a-1h) were effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II) with Ki values in the range of 80.60 ± 17.90 to 492.53 ± 95.23 nM for hCA I, 102.88 ± 18.44 to 461.09 ± 102.50 nM for hCA II. 1f compound shows a remarkable inhibitory effect of hCA I and hCA II isoenzymes among the new synthesized compounds. The new derivatives of naphthalenylmethylen hydrazine can be a potent inhibitor of both cytosolic CA isoenzymes which are commonly used in the pharmaceutical industries and medical areas.
Yazarlar (2)
1
Hanif Şirinzade
2
Esra Dilek
Anahtar Kelimeler
Carbonic anhydrase
Enzyme inhibition
FNICKFVHHJDGAT-UHFFFAOYSA-N
LMSLPMMHNMFLHP-UHFFFAOYSA-N
LRSPBPNYAZMQFT-UNOMPAQXSA-N
Naphthalenylmethylen hydrazine
QBEFRSDYCFCLQT-UHFFFAOYSA-N
Synthesis
TVSPUNGBTKHUFA-UHFFFAOYSA-N
UAIVSWGFFGHSMW-UHFFFAOYSA-N
UUAOQBZZPLCVHT-UHFFFAOYSA-N
VGPSXAJHUXUYBG-UHFFFAOYSA-N
Kurumlar
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Molecular Structure
Q2
SJR Skoru0,628
H-Index134
YayıncıElsevier B.V.
ÜlkeNetherlands
Analytical Chemistry (Q2)
Inorganic Chemistry (Q2)
Organic Chemistry (Q2)
Spectroscopy (Q2)
Metrikler
14
Atıf
2
Yazar
12
Anahtar Kelime