Scopus
YÖKSİS Eşleşti
Evaluation of Naphthalenylmethylen Hydrazine Derivatives as Potent Inhibitors on, Antiatherogenic Enzymes, Paraoxonase I and Acetylcholinesterase Activities
ChemistrySelect · Şubat 2022
YÖKSİS Kayıtları
Evaluation of Naphthalenylmethylen Hydrazine Derivatives as Potent Inhibitors on, Antiatherogenic Enzymes, Paraoxonase I and Acetylcholinesterase Activities
ChemistrySelect · 2022 SCI-Expanded
DOÇENT HANİF ŞİRİNZADE →
Makale Bilgileri
DergiChemistrySelect
Yayın TarihiŞubat 2022
Cilt / Sayfa7
Scopus ID2-s2.0-85128069293
Özet
Acetylcholinesterase (AChE) and paraoxonase 1 (PON1) are two important serum ester hydrolases that have antiatherosclerotic effect by inhibiting the oxidation of lipid peroxides. In addition, AChE inhibitors are target molecules for the treatment of Alzheimer's. Naphthalene derivatives are important molecules in the field of pharmacology due to their wide range of biological activities. In this study, the inhibition effects of naphthalenylmethylen hydrazine derivatives on these two metabolic enzymes were investigated. IC50 values of these molecules were determined in the range of 0.158 μM to 6.862 μM against PON1, 0.0214 μM to 0.675 μM against AChE. As a result, naphthalenylmethylen hydrazine derivatives had strong inhibition effect on both enzymes. In this context, we hope that the results obtained in this study contribute to the determination of the side effects of current and new naphthalene-based pharmacological compounds to be developed. And also be effective in the synthesis studies of new AChE inhibitors.
Yazarlar (3)
1
Hanif Şirinzade
2
Esra Dilek
3
Zuhal Alım
ORCID: 0000-0001-7216-1194
Kurumlar
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kırşehir Ahi Evran Üniversitesi
Kirsehir Turkey
Metrikler
14
Atıf
3
Yazar