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Cardiac safety of Diclofenac at a single dose in ram

The Scientific World Journal · Ekim 2013

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YÖKSİS Kayıtları
Cardiac Safety of Diclofenac at a Single Dose in Ram
SCIENTIFIC WORLD JOURNAL · 2013 SCI-Expanded
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Makale Bilgileri

DergiThe Scientific World Journal
Yayın TarihiEkim 2013
Cilt / Sayfa2013
DOI10.1155/2013/808731
Scopus ID2-s2.0-84886572185
Erişim🔓 Açık Erişim
Özet Nonsteroidal anti-inflammatory drugs are frequently prescribed drug group in human and veterinary medicine. However, diclofenac, a traditional nonsteroidal anti-inflammatory drug, related to cardiotoxicity is reported, and blood cardiac damage markers may increase within the first hours after damage. The aim of the current research was to determine the effect of diclofenac on the blood cardiac damage markers. Single dose of diclofenac (2.5 mg/kg, IM) was injected to 6 rams. Blood samples were collected in before (0 hour, control) and 6 hours after injection. Specific (troponin I, and creatine kinase-MB) and nonspecific (lactate dehydrogenase, aspartate aminotransferase) blood cardiac damage marker concentrations, routine biochemical (hepatic damage, renal damage, lipid metabolism, glucose, and phosphorus) parameters, and hemogram values were measured. Diclofenac increased (P < 0.05) specific (troponin I) and nonspecific cardiac (lactate dehydrogenase, aspartate aminotransferase), hepatic (aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase), and muscular (creatine kinase) damage markers and high density lipoprotein level, while it decreased (P < 0.05) low density lipoprotein level. Moreover, diclofenac decreased (P < 0.05) white blood cell counts and increased (P < 0.05) red blood cell counts. In conclusion, it may be stated that diclofenac shows slight cardiotoxicity, whereas it may show potent hepatic and muscular damage effects at an intramuscularly single dose in sheep. Thereby, repeated injections of diclofenac may be more harmful in sheep. © 2013 Ayse Er et al.

Yazarlar (4)

1
A. Er
2
Burak Dik
3
Orhan Corum
ORCID: 0000-0003-3168-2510
4
Gul Cetin

Kurumlar

Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey

Metrikler

14
Atıf
4
Yazar

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BD
BURAK DİK
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