Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effects of florfenicol on the values of serum tumor necrosis factor- α and other biochemical markers in lipopolysaccharide-induced endotoxemia in brown trout
Mediators of Inflammation · Ocak 2014
YÖKSİS Kayıtları
The Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor and Other Biochemical Markers in Lipopolysaccharide Induced Endotoxemia in Brown Trout
Mediators of Inflammation · 2014 SCI
PROFESÖR BURAK DİK →
The effects of florfenicol on the values of serum tumor necrosis factor and other biochemical markers in lipopolysaccharide induced endotoxemia in brown trout
Mediators of Inflammation · 2014 SCI
PROFESÖR AYŞE ER →
Makale Bilgileri
DergiMediators of Inflammation
Yayın TarihiOcak 2014
Cilt / Sayfa2014
Scopus ID2-s2.0-84901020445
Erişim🔓 Açık Erişim
Özet
The aim of the present study was to determine the effects of florfenicol on the expected changes in sTNF-α, damage markers of the liver and kidney, and the lipid metabolism parameters in endotoxemic brown trout. Ninety-six brown trout were included in this study. After six of the fish were reserved as the control group, the remaining 90 fish were divided equally into 3 groups as follows: LPS (2 mg/kg, IP), LPS (2 mg/kg, IP) + florfenicol (40 mg/kg, IM), and florfenicol (40 mg/kg, IM). Blood samples were obtained from the tail of the fish at 1.5, 3, 6, 10, and 24 hours. The levels of sTNF-α were determined by ELISA and biochemical markers were evaluated with an autoanalyzer. A significant increase was observed in the values of sTNF-α in the LPS and LPS + florfenicol groups (P < 0.05). Significant increases were found in the kidney and liver damage determinants in the LPS and LPS + florfenicol groups (P < 0.05). Irregular changes in the lipid metabolism parameters were observed in all the subgroups. In conclusion, florfenicol does not affect the increases of sTNF-α caused by LPS and does not prevent liver or kidney damage; at least, it can be said that florfenicol does not have any evident positive effects on the acute endotoxemia of fish. © 2014 Ayse Er and Burak Dik.
Yazarlar (2)
1
A. Er
2
Burak Dik
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
26
Atıf
2
Yazar