Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
The impact of ambroxol on the anti-inflammatory effect of azithromycin in lung tissue
Veterinarski Arhiv · Ocak 2021
YÖKSİS Kayıtları
The impact of ambroxol on the anti-inflammatory effect of azithromycin in
lung tissue
Veterinarski Arhiv · 2021 pub med
Prof. Dr. AYŞE ER →
The impact of ambroxol on the anti-inflammatory effect of azithromycin in lung tissue
Veterinarski Arhiv · 2021 SCI-Expanded
Prof. Dr. BURAK DİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Vomeronasal Organ in Angora Goats Capra Hircus
2001 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. EMRULLAH EKEN →
The Effects of Aflatoxin and Glucomannan on Coagulation Parameters in Rabbits
2009 ISSN: 0372-5480 SCI-Expanded 3 atıf
Prof. Dr. NURCAN DÖNMEZ →
The evaluation of endometrial cytology in cows with acute and chronic endometritis
2015 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Miyocarditis associated with foot and mouth disease in suckling calves
2015 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Comparison of two different primer sets for detection of Pasteurellacaballi in bronchoalveolar lavage fl uids samples from thoroughbred Arabian foals using PCR
2016 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. HASAN HÜSEYİN HADİMLİ →
The relationship of copper concentrations in feed and plasma to developmental orthopedic disease in foals
2016 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
Comparison of two different primer sets for detection of Pasteurellacaballi in bronchoalveolar lavage fluids samples from thoroughbredArabian foals using PCR
2016 ISSN: 0372-5480 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
Comparison of two different primer sets for detection of Pasteurellacaballi in bronchoalveolar lavage fl uids samples from thoroughbredArabian foals using PCR
2016 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. MEHMET MADEN →
The Vomeronasal Organ In Angora Goats Capra Hircus
2001 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. KAMİL BEŞOLUK →
The Vomeronasal Organ in Angora Goats (Capra hircus)
2001 ISSN: 0372-5480 SCI
Prof. Dr. KAMİL BEŞOLUK →
Histological and histomorphometric studies on the cerebellar cortex and silver stained nucleolus organizer regions of Purkinje neurons in chronic morphine-treated rats
2018 ISSN: 0372-5480 SCI
Prof. Dr. İLHAMİ ÇELİK →
The impact of ambroxol on the anti-inflammatory effect of azithromycin in
lung tissue
2021 ISSN: 0372-5480 pub med
Prof. Dr. AYŞE ER →
The effect of intra-articular platelet-rich plasma, bio-physically activated
PRP and mesenchymal stem cell administration for interleukins in dogs
with osteoarthritis
2022 ISSN: 0372-5480 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
The effect of intra-articular platelet-rich plasma, bio-physically activated PRP and mesenchymal stem cell administration for interleukins in dogs with osteoarthritis
2022 ISSN: 0372-5480 SCI-Expanded Q4
Prof. Dr. KAMİL ÜNEY →
The protective effects of Nigella sativa, thymoquinone and bentonite in experimental aflatoxicosis model in broilers
2023 ISSN: 0372-5480 SCI-Expanded Q4
Doç. Dr. MEHMET BURAK ATEŞ →
Investigation of the tumor microenvironment, hypoxia and angiogenesis by immunohistochemical and histopathological methods in canine mammary tumors
2023 ISSN: 0372-5480 Science Citation Index Expanded (SciSearch®) Journal Citation Reports/Science Edition SCOPUS Zoological Record Biological Abstracts BIOSIS Previews CAB Abstracts (Index Veterinarius, Veterinary Bulletin) FISHLIT
Prof. Dr. FATİH HATİPOĞLU →
The protective effects of Nigella sativa, thymoquinone and bentonite in experimental aflatoxicosis model in broilers
2023 ISSN: 0372-5480 CABI, EBSCO, Scobus
Prof. Dr. MUSTAFA ORTATATLI →
The protective effects of Nigella sativa, thymoquinone and bentonite
in experimental aflatoxicosis model in broilers
2023 ISSN: 0372-5480 SCI-Expanded Q4
Prof. Dr. HALİS UĞUZ →
In-vitro antiviral activity of Neem (Azadirachta indica L.) Bark extract against
BCoV, BHV-1, BPIV-3, and BEVs
2025 ISSN: 0372-5480 SCI-Expanded
Arş. Gör. HATİCE PELİN ASLIM →
High point seroprevalence of Toxoplasma gondii and Neospora caninum in sheep with abortion history in the central part of Türkiye
2025 ISSN: 0372-5480 SCI-Expanded
Doç. Dr. ONUR CEYLAN →
Makale Bilgileri
Dergi
Veterinarski Arhiv
ISSN03725480
Yayın TarihiOcak 2021
Cilt / Sayfa91 · 665-671
Scopus ID2-s2.0-85125100862
Erişim🔓 Açık Erişim
Özet
The aim of this study was to compare the effects of two different doses of ambroxol (AMB) co-administered with azithromycin (AZIT) on the concentrations of bronchoalveolar lavage fluid (BALF) cytokines and serum biochemical parameters in an lipopolysaccharide (LPS)-induced acute lung injury mouse model. A total of 78 male Swiss albino mice were used for this investigation. After six mice had been separated as the control group (0 hours), the remaining animals were divided into the following three equal groups: LPS, LPS+AZIT+AMB30 and LPS+AZIT+AMB70. LPS, AZIT and AMB were administered intraperitoneally. BALF and serum samples were collected before (0 hour) and after applications at 4, 8, 16 and 24 hours under general anaesthesia, and then all mice were euthanised by cervical dislocation. Concentrations of tumor necrosis factor (TNF)α, interleukin (IL)-6 and IL-10 in BALF and aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine concentrations in serum were determined. Elevated TNFα and IL-6 concentrations in the LPS group were prevented at 8 and 16 hours in LPS+AZIT+AMB30 group. In addition, both treatment groups inhibited elevated IL-6 concentrations in the LPS group at 16 hours. LPS+AZIT+AMB30 and LPS+AZIT+AMB70 increased IL-10 concentrations at 16 and 4 hours, respectively. LPS caused significant elevations in urea concentrations at all sampling times and statistical fluctuations in other parameters at different sampling times. The increased ALP concentration in LPS group decreased in the treatment groups at 8 hours. In conclusion, the combination of low-dose AMB and AZIT may achieve beneficial effects in pulmonary infections by influencing the cytokine network.
Yazarlar (5)
1
A. Er
2
Burak Dik
3
Devran Coskun
ORCID: 0000-0003-1151-1861
4
Hatice Eser Faki
5
Emre Bahcivan
Anahtar Kelimeler
Acute lung injury
Ambroxol
Azithromycin
BALF
Cytokine
Kurumlar
Kafkas Üniversitesi, Veteriner Fakültesi
Kars Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
Scimago Dergi (ISSN Eşleşmesi)
Veterinarski Arhiv
Q3
OA
SJR Skoru0,208
H-Index38
YayıncıUniversity of Zagreb, Facultty of Veterinary Medicine
ÜlkeCroatia
Veterinary (miscellaneous) (Q3)