CANLI
Yükleniyor Veriler getiriliyor…
/ Makaleler / Scopus Detay
Scopus 🔓 Açık Erişim YÖKSİS Eşleşti

Pomegranate peel extract, N-Acetylcysteine and their combination with Ornipural alleviate Cadmium-induced toxicity in rats

Journal of Veterinary Medical Science · Ocak 2023

YÖKSİS DOI Eşleşmesi Bulundu

Bu Scopus makalesi YÖKSİS veritabanında da kayıtlı. Aşağıda YÖKSİS verilerini görebilirsiniz.

YÖKSİS Kayıtları
Pomegranate peel extract, N-Acetylcysteine and their combination with Ornipural alleviate Cadmium-induced toxicity in rats
Japanese Society of Veterinary Science · 2023 SCI-Expanded
PROFESÖR BURAK DİK →

Makale Bilgileri

DergiJournal of Veterinary Medical Science
Yayın TarihiOcak 2023
Cilt / Sayfa85 · 990-997
DOI10.1292/jvms.22-0375
Scopus ID2-s2.0-85170079759
Erişim🔓 Açık Erişim
Özet Cadmium is a major environmental pollutant and a highly toxic metal. It was aimed to determine the effects of pomegranate peel extract (PPE), N-acetylcysteine (NAC) alone and along with Ornipural on cadmium-induced toxicity. Forty-six Wistar Albino male rats were divided into 6 groups and the groups were formed into healthy control, Cadmium group (5 mg/kg/day, oral), Cadmium + Pomegranate peel extract (500 mg/kg, oral), Cadmium + N-acetylcysteine (100 mg/kg, oral), Cadmium + Pomegranate peel extract (500 mg/kg, oral) + Ornipural (1 mL/kg, subcutaneous) and Cadmium + N-acetylcysteine (100 mg/kg, oral) + Ornipural (1 mL/kg, subcutaneous). Cadmium accumulated heavily in both liver and kidney tissue. The administration of N-acetylcysteine and pomegranate peel extract alone reduced cadmium levels in both tissues. N-acetylcysteine treatment prevented the increase in ALT and MDA levels by cadmium damage. N-acetylcysteine + Ornipural treatment inhibited the increase in liver 8-OHdG level in the liver. N-acetylcysteine and N-acetylcysteine + Ornipural treatments prevented the reduced serum MMP2 level. N-acetylcysteine and Pomegranate peel extract + Ornipural treatments significantly reduced the increased liver iNOS level in the liver. In conclusion, NAC therapy may be a successful treatment option for cadmium toxicity. However, further research is needed on the effects of PPE and Ornipural combinations for the treatment of cadmium toxicity. In future studies, various doses of these treatment options (with chelators) should be investigated for cadmium toxicity.

Yazarlar (4)

1
Yasemin Korkmaz
ORCID: 0000-0002-1990-2691
2
Huseyin Gungor
ORCID: 0000-0002-2506-3855
3
Ahmet Demirbaş
4
Burak Dik

Anahtar Kelimeler

cadmium heavy metal n-acetylcysteine pomegranate toxicity

Kurumlar

Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey

Metrikler

1
Atıf
4
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

BD
BURAK DİK
PROFESÖR

Hızlı Erişim

DOI ile aç Scopus'ta aç Makaleler listesi