Scopus
🔓 Açık Erişim
Triglyceride-glucose index levels in patients with congenital hypogonadotropic hypogonadism and the relationship with endothelial dysfunction and insulin resistance
Endokrynologia Polska · Haziran 2021
Makale Bilgileri
DergiEndokrynologia Polska
Yayın TarihiHaziran 2021
Cilt / Sayfa72 · 232-237
Scopus ID2-s2.0-85112129932
Erişim🔓 Açık Erişim
Özet
Introduction: The risk of cardiometabolic diseases is increased in patients with hypogonadism. The triglyceride-glucose (TyG) index is a novel surrogate marker of insulin resistance and is associated with cardiovascular diseases. We investigated the TyG index levels and the relationship with endothelial dysfunction and insulin resistance in patients with congenital hypogonadotropic hypogonadism (CHH). Material and methods: A total of 98 patients with CHH (mean age 21.66 ± 1.99 years) and 98 healthy control subjects (mean age 21.69 ± 1.21 years) were enrolled. The demographic parameters, TyG index, asymmetric dimethylarginine (ADMA), high-sensitivity C-reactive protein (hs-CRP), and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured for all participants. Results: The patients had higher waist circumference (p < 0.001), triglycerides (p = 0.001), insulin (p = 0.003), HOMA-IR (p = 0.002), ADMA (p < 0.001), and TyG index (p < 0.001) levels and lower HDL-C (p = 0.044) and total testosterone (p < 0.001) levels compared to healthy control subjects. TyG index levels significantly correlated with the ADMA (r = 0.31, p = 0.003) and HOMA-IR (r = 0.32, p < 0.001) levels. TyG index was also determinant of HOMA-IR levels (ß = 0.20, p = 0.018). Conclusion: The results of the present study show that patients with CHH had increased TyG index levels. Also, the TyG index is independently associated with insulin resistance in patients with CHH. Long-term follow-up studies are warranted to find out the role of the TyG index in determining cardiometabolic risk in patients with hypogonadism.
Yazarlar (10)
1
Ibrahim Demirci
ORCID: 0000-0002-6808-8550
2
Cem Haymana
3
Burcu Candemir
ORCID: 0000-0003-1800-6235
4
Coskun Meric
ORCID: 0000-0002-0766-0517
5
Bagdagul Yuksel
ORCID: 0000-0002-8023-2666
6
Mithat Eser
ORCID: 0000-0001-8089-1146
7
Onur Akın
8
Safak Akin
9
Nese Ersoz Gulcelik
ORCID: 0000-0001-8212-5752
10
Alper Sonmez
Anahtar Kelimeler
ADMA
Cardiovascular risk
Congenital hypogonadotropic hypogonadism
Hypogonadism
Insulin resistance
Triglyceride-glucose index
Kurumlar
Gülhane Eğitim ve Araştırma Hastanesi
Ankara Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
13
Atıf
10
Yazar
6
Anahtar Kelime