Scopus
🔓 Açık Erişim
Clinical outcomes of non-diabetic COVID-19 patients with different blood glucose levels: a nationwide Turkish study (TurCoGlycemia)
Endocrine · Ağustos 2021
Makale Bilgileri
DergiEndocrine
Yayın TarihiAğustos 2021
Cilt / Sayfa73 · 261-269
Scopus ID2-s2.0-85108585656
Erişim🔓 Açık Erişim
Özet
Purpose: New coronavirus disease 2019 (COVID-19) has a worse prognosis in patients with diabetes. However, there are insufficient data about the effect of hyperglycemia on COVID-19 prognosis in non-diabetic patients. This study aimed to investigate the relationship between random blood glucose levels measured at the time of diagnosis and prognosis of COVID-19 disease in non-diabetic patients. Methods: A nationwide retrospective cohort of non-diabetic patients with confirmed COVID-19 infection from 11 March to 30 May 2020 in the Turkish Ministry of Health database was investigated. The patients were stratified into three groups according to blood glucose levels which were <100 mg/dL in group-1, in the range of 100–139 mg/dl in group-2, and the range of 140–199 mg/dl in group-3. Clinical characteristics and outcomes were compared among the groups. The primary outcome was mortality. Results: A total of 12,817 non-diabetic patients (median age [IQR]: 44 [25] years, females: 50.9%) were included. Patients in group-2 (5%) and group-3 (14%) had higher mortality rates than patients in group-1 (2.1%). The rates of hospitalization, hospital stays longer than 8 days, intensive care unit (ICU) admission, ICU stay more than 6 days, and mechanical ventilation were also significantly higher in group-3 patients. Likewise, glucose levels in the range of 140–199 mg/dL were an independent associate of mortality and composite of ICU admission and/or mechanical ventilation. Conclusion: Hyperglycemia at the time of COVID-19 diagnosis is associated with poor prognosis in non-diabetic patients. Clinicians should be more careful in the treatment of non-diabetic COVID-19 patients with hyperglycemia.
Yazarlar (18)
1
Cem Haymana
2
Ibrahim Demirci
ORCID: 0000-0002-6808-8550
3
İlker Taşçı
4
Erman Çakal
ORCID: 0000-0003-4455-7276
5
Serpil Salman
6
Derun Ertugrul
7
Naim Ata
8
Ugur Unluturk
9
Selçuk Daǧdelen
10
Aysegul Atmaca
11
Mustafa Sahin
ORCID: 0000-0002-4718-0083
12
Osman Celik
13
Tevfik Demir
ORCID: 0000-0003-0319-9572
14
Rıfat Emral
15
Ibrahim Sahin
16
Murat Caglayan
17
Ilhan Satman
18
Alper Sonmez
Anahtar Kelimeler
COVID-19
Hospitalization
Hyperglycemia
ICU admission
Mechanical ventilation
Mortality
SARS-CoV-2
Kurumlar
Ankara Provincial Health Directorate
Ankara Turkey
Ankara Üniversitesi
Ankara Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Hacettepe Üniversitesi
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
İstanbul Tıp Fakültesi
Istanbul Turkey
Medica Clinic
Istanbul Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
T.C. Sağlık Bakanlığı,
Ankara Turkey
Turkish Institute of Public Health and Chronic Diseases
Istanbul Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
5
Atıf
18
Yazar
7
Anahtar Kelime