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The Role of Histogram-Based Textural Analysis of18F-FDG PET/CT in Evaluating Tumor Heterogeneity and Predicting the Prognosis of Invasive Lung Adenocarcinoma

Molecular Imaging and Radionuclide Therapy · Şubat 2022

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YÖKSİS Kayıtları
The Role of Histogram-Based Textural Analysis of 18F-FDG PET/CT in Evaluating Tumor Heterogeneity and Predicting the Prognosis of Invasive Lung Adenocarcinoma
Molecular Imaging and Radionuclide Therapy · 2022 ESCI
Doç. Dr. HASAN ÖNNER →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 7 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
68Ga-PSMA-Avid Sinonasal Intestinal-Type Adenocarcinoma
2025 ISSN: 2146-1414 ESCI
Dr. Öğr. Üyesi MUHAMMET FATİH GÖKMEN →
The Role of Histogram-Based Textural Analysis of 18F-FDG PET/CT in Evaluating Tumor Heterogeneity and Predicting the Prognosis of Invasive Lung Adenocarcinoma
2022 ISSN: 2146-1414 ESCI
Doç. Dr. HASAN ÖNNER →
Characteristics of Radiopharmaceutical Uptake in Primary Tumor and Metastatic Lesions of Prostate Carcinoma: Comparison of Oligometastatic with Multimetastatic Disease
2023 ISSN: 2146-1414 Emerging sources citation index
Doç. Dr. HASAN ÖNNER →
Physiological Biodistribution of 68Ga-DOTA-TATE in Normal Subjects
2021 ISSN: 2146-1414 ESCI
Dr. Öğr. Üyesi KEVSER ÖKSÜZOĞLU →
Nasolacrimal Duct Obstruction on <sup>131</sup>I SPECT/CT: Atypical False-positive Paranasal Radioiodine Uptake as a Complication of Single-dose RAI Treatment
2022 ISSN: 2146-1414 ESCI
Dr. Öğr. Üyesi KEVSER ÖKSÜZOĞLU →
Extensive Malignant Thrombus Revealed by 18F-FDG PET/CT in Patient with Papillary Thyroid Cancer
2025 ISSN: 2146-1414 ESCI
Doç. Dr. HASAN ÖNNER →
Comparison of 68Ga-FAPI-04 and 68Ga-PSMA in a Case of Interstitial Lung Disease
2025 ISSN: 2146-1414 ESCI
Doç. Dr. HASAN ÖNNER →

Makale Bilgileri

Dergi Molecular Imaging and Radionuclide Therapy
ISSN21461414
Yayın TarihiŞubat 2022
Cilt / Sayfa31 · 33-41
DOI10.4274/mirt.galenos.2021.79037
Scopus ID2-s2.0-85124183306
Erişim🔓 Açık Erişim
Özet Objectives: This study aimed to investigate the contributory role of histogram-based textural features (HBTFs) extracted from18fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in tumoral heterogeneity (TH) evaluation and invasive lung adenocarcinoma (ILA) prognosis prediction. Methods: This retrospective study analyzed the data of 72 patients with ILA who underwent18F-FDG PET/CT followed by surgical resection. The maximum standardized uptake value (SUVmax), metabolic tumor volume, and total lesion glycolysis values were calculated for each tumor. Additionally, HBTFs were extracted from18F-FDG PET/CT images using the software program. ILA was classified into the following five histopathological subtypes according to the predominant pattern: Lepidic adenocarcinoma (LA), acinar adenocarcinoma, papillary adenocarcinoma, solid adenocarcinoma (SA), and micropapillary adenocarcinoma (MA). Differences between18F-FDG PET/CT parameters and histopathological subtypes were evaluated using non-parametric tests. The study endpoints include overall survival (OS) and progression-free survival (PFS). The prognostic values of clinicopathological factors and18F-FDG PET/CT parameters were evaluated using the Cox regression analyses. Results: The median SUVmax and entropy values were significantly higher in SA-MA, whereas lower in LA. The median energy-uniformity value of the LA was significantly higher than the others. Among all parameters, only skewness and kurtosis were significantly associated with lymph node involvement status. The median values for follow-up time, PFS, and OS were 31.26, 16.07, and 20.87 months, respectively. The univariate Cox regression analysis showed that lymph node involvement was the only significant predictor for PFS. The multivariate Cox regression analysis revealed that higher SUVmax (≥11.69) and advanced stage (IIB-IIIA) were significantly associated with poorer OS [hazard ratio (HR): 3.580, p=0.024 and HR: 7.608, p=0.007, respectively]. Conclusion: HBTFs were tightly associated with clinicopathological factors causing TH. Among the18F-FDG PET/CT parameters, only skewness and kurtosis were associated with lymph node involvement, whereas SUVmax was the only independent predictor of OS. TH measurement with HBTFs may contribute to conventional metabolic parameters in guiding precision medicine for ILA.

Yazarlar (4)

1
H. Önner
ORCID: 0000-0003-1002-2097
2
Nazım Coşkun
3
Mustafa Erol
4
Meryem İlkay Eren Karanis

Anahtar Kelimeler

Fluorodeoxyglucose Lung adenocarcinoma Prognosis Radiomics Textural analysis

Kurumlar

University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Molecular Imaging and Radionuclide Therapy
Q3 OA
SJR Skoru0,274
H-Index17
YayıncıGalenos Publishing House
ÜlkeTurkey
Radiology, Nuclear Medicine and Imaging (Q3)
Dergi sayfasına git

Metrikler

10
Atıf
4
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

HÖ
HASAN ÖNNER
Doç. Dr.

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