Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Inhibition of corneal neovascularization by topical and subconjunctival tigecycline
Journal of Ophthalmology · Ocak 2014
YÖKSİS Kayıtları
Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
Journal of Ophthalmology · 2014 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ NEJAT ÜNLÜKAL →
Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
Journal of Ophthalmology · 2014 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ NEJAT ÜNLÜKAL →
Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
Journal of Ophthalmology · 2014 SCI-Expanded
PROFESÖR ENDER ERDOĞAN →
Makale Bilgileri
DergiJournal of Ophthalmology
Yayın TarihiOcak 2014
Cilt / Sayfa2014
Scopus ID2-s2.0-84907381736
Erişim🔓 Açık Erişim
Özet
Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization. Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days. Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically. Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2-55.8%) and 33.5% (95% CI, 26.6-39.2%), respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P = 0.03 and P < 0.001, resp.). Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups. Conclusion. Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization. Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.
Yazarlar (12)
1
Sertan Goktas
2
Ender Erdoğan
3
Rabia Sakarya
4
Yasar Sakarya
5
Mustafa Yilmaz
6
Muammer Ozcimen
7
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
8
Ismail Alpfidan
9
Fatih Tas
10
Erkan Erdogan
11
Abdulkadir Bukus
12
Ismail Senol Ivacik
Kurumlar
Konya Meram Training and Research Hospital
Konya Turkey
Mevlana Üniversitesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
20
Atıf
12
Yazar